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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Alzheimers Dement. 2015 Aug 29;12(2):164–169. doi: 10.1016/j.jalz.2015.07.492

Table 1. Brain regions and stains.

For “A” score^ For “B” score# For “C” score*
Aβ Stain NFT Stain NP Stain
Middle frontal gyrus X X X
Superior and middle temporal gyri X X X
Inferior parietal lobule X X X
Occipital Cortex (BA 17 & 18) X
Hippocampus and entorhinal cortex X X
Basal ganglia at anterior commissure X
Midbrain including substantia nigra X
Cerebellar cortex X

Staining methods used by different sites included:

^

immunohistochemistry for Aβ (antibodies (source) 6E10 (Covance), 6F/3D (DAKO), 4G8 (Covance), NAB228 (University of Pennsylvania), 10D5 (Elan), and AB5074P and AB5078P (Chemicon);

#

immunohistochemistry for neurofibrillary degeneration (antibodies PHF-1 (Dr. Peter Davies), Tau (DAKO), AT8 (Autogen Bioclear), MN1020 (Thermo Scientific), and

*

histochemistry (Thioflavin S or Bielschowsky stain) or immunohistochemistry (NM1020 or PHF-1) for neuritic plaques. Staining methods used by site are shown in Table S1.