. Author manuscript; available in PMC: 2015 Dec 1.

Published in final edited form as: Anesthesiology. 2014 Dec;121(6):1281–1291. doi: 10.1097/ALN.0000000000000391

Table 2.

Intravenous methadone pharmacokinetic parameters

	Control	Cyclosporine	Control	Cyclosporine
	R-Methadone		S-Methadone
Plasma C_max (ng/ml)	22.6 ± 6.4	18.8 ± 5.5^*	32.2 ± 7.9	25.3 ± 7.2^*
Plasma AUC_0-24 (ng/ml•h)	174 ± 31	180 ± 41	276 ± 47	282 ± 68
Plasma AUC_0-24/dose ratio (cyclosporine/control)		1.03 (0.97, 1.09)		1.00 (0.94, 1.08)
Urine %dose eliminated (0-24 h)	6.3 ± 2.8	7.8 ± 3.2	5.1 ± 2.4	6.1 ± 2.5

All data are reported as mean ± standard deviation except AUC ratios (cyclosporine/control), which are the geometric mean and 90% confidence interval (n=12).

p<0.05 vs control

AUC=area under the plasma concentration-time curve; C_max= peak plasma concentration