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. 2015 Jul 30;172(18):4443–4453. doi: 10.1111/bph.13225

Figure 2.

Figure 2

Cardiomyocyte hypertrophy. Cardiomyocyte area (A) and width (B) were assessed. Cardiomyocyte size was increased in db/db mice. Treatment with Ang-(1–7) reversed this change. Co-administration of Ang-(1–7) with either PD123319, A-779, icatibant or L-NAME, but not losartan, blocked the effects of treatment (Hz – heterozygous; db – diabetic; a.u. – arbitrary units). *P < 0.05. Significantly different compared with db + Ang-(1–7), †P < 0.05; ††P < 0.01; or †††P < 0.001; calculated using one-way anova.