Bone marrow (BM)-derived and circulating EPC counts and BM-derived MSC counts. EPC from the BM (A) and circulation (B), as well as BM-derived MSC (C), were significantly decreased in db/db mice. Ang-(1–7) administration significantly increased these outcomes. Ang-(1–7) effects were blocked by PD123319, A-779, L-NAME and icatibant, but not losartan (Hz – heterozygous; db – diabetic). *P < 0.05; **P < 0.01. Significantly different compared with db + Ang-(1–7), †P < 0.05; ††P < 0.01, calculated using one-way anova.