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GSK1016790A induced lung damage in wt mice and KCa3.1−/− mice. H&E staining in sections of lungs infused with vehicle (A, B) or GSK1016790A (C, D) from wt (A, C) and KCa3.1−/− mice (B, D). Note the haemorrhage in wt lungs that was not seen in the KCa3.1−/− lungs. (E) Summary data. Scale bar = 100 μm in panels. Data points are means ± SEM (n = 4–6). Student’s t-test: *P < 0.05 versus wt mice.
