Skip to main content
. 2015 Jul 24;172(18):4493–4505. doi: 10.1111/bph.13234

Figure 5.

Figure 5

TRPV4 and relaxation of pulmonary arteries from wt and KCa3.1−/− mice. (A) Relaxations induced by GSK1016790A in the first- and second-order intrapulmonary branches of the right main pulmonary artery from wt and KCa3.1−/− mice. (B) Relaxations induced by GSK1016790A in the absence and the presence of a blocker of TRPV4 channels, HC067047, an inhibitor of NOS, L-NOARG, and after removal of the endothelium (without E) in first-order intrapulmonary arteries of the right main pulmonary artery from either genotype. (C) Relaxations induced by GSK1016790A in first-order intrapulmonary arteries of the right main pulmonary artery in the absence and the presence of blockers of KCa2, UCL1684 and KCa3.1 channels, TRAM-34. (D) Relaxations induced by SNP in first-order intrapulmonary arteries of the right main pulmonary artery from wt and KCa3.1−/− mice. The experiments were performed in the presence of indomethacin. Data are means ± SEM (n = 7). One-way anova followed by Tukey’s post hoc test: *P < 0.05 versus wt, #P < 0.05 versus control pulmonary artery with endothelium (E).