Skip to main content
. 2015 Jul 24;172(18):4493–4505. doi: 10.1111/bph.13234

Figure 6.

Figure 6

Activation of TRPV4 currents and co-activation of KCa channels in pulmonary artery endothelial cells from wt and KCa3.1−/− mice. (A) Representative whole-cell currents as recorded immediately after establishing the fast whole-cell configuration. (B) TRPV4 currents activated by the GSK1016790A (200 nM) and blockade by HC067047 (1 μM). (C) Co-activation of TRAM-34 (1 μM)-sensitive KCa3.1 currents and UCL1684 (1 μM)-sensitive KCa2.3 currents in wt and of UCL1684-sensitive KCa2.3 currents in KCa3.1−/−. Panels on right: currents normalized to cell capacitance. Numbers refer to the n of cells studied per genotype. Data represent means ± SEM.