Table 2.

Agonist or antagonist activities of γ-oryzanol for dopamine receptors (DRD1–DRD5)

	Agonist		Antagonist
	% Activity	Z-factor	% Inhibition	Z-factor
DRD1	0	0.73	10	0.84
DRD2L	1	0.79	−5	0.81
DRD2S	2	0.81	5	0.91
DRD3	13	0.48	−13	0.79
DRD4	1	0.86	−2	0.77
DRD5	−2	0.75	9	0.87

Percentage of activity in γ-oryzanol for each dopamine receptor was calculated relative to the basal or maximal agonist values of dopamine. Percentage of inhibition by γ-oryzanol for each dopamine receptor was calculated relative to the basal or EC₈₀ values for dopamine (antagonist activity). GPCR targets: DRD1, dopamine D₁ receptor; DRD2L, long form of the dopamine D₂ receptor; DRD2S, short form of the dopamine D₂ receptor; DRD3, dopamine D₃ receptor; DRD4, dopamine D₄ receptor; DRD5, dopamine D₅ receptor.