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. 2015 Jul 31;172(18):4546–4559. doi: 10.1111/bph.13239

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Published 2015. This article is a U.S. Government work and is in the public domain in the USA.

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Effect of (R)-ketamine and (S)-ketamine on the expression of monomeric serine racemase protein. (A–D) Thirty-six hours after treatment with the indicated concentrations of (R)-ketamine (panels A and C) or (S)-ketamine (panels B and D), PC-12 (panels A and B) and 1321N1 (panels C and D) cell lysates were prepared and then immunoblotted with anti-serine racemase (m-SR) antibody. Relative levels of m-SR after quantification and normalization with β-actin are shown in the bars. (E, F), Primary cultures of rat neuronal cells isolated from cortex (panel E) and hippocampus (panel F) were treated with vehicle, (R)-ketamine (1 μM) or (S)-ketamine (0.5 μM) for 36 h and then processed for m-SR immunoblot analysis. Data represent the average ± SD of three independent experiments. *P < 0.05; **P < 0.01 as compared with the control cells.