Figure 8.

Correlation between CADSS score, plasma d-serine concentration and (R)- and (S)-ketamine levels in MDD patients, based upon the data reported by Moaddel et al. (2015). (A) Left Y-axis: The effect of a 40 min i.v. infusion of 0.5 mg·kg⁻¹ (R,S)-ketamine on the plasma concentration of d-serine in MDD patients was determined from baseline post-infusion levels. Right Y-axis: Changes in the average CADSS scores over time in MDD patients following administration of (R,S)-ketamine. (B) The plasma concentrations of (R)-ketamine and (S)-ketamine following a 40 min i.v. infusion of 0.5 mg·kg⁻¹ (R,S)-ketamine in MDD patients were determined from baseline post-infusion levels.