Table 1.
The change in intracellular and extracellular d-serine concentrations in primary neuronal cells derived from rat cortex and hippocampus produced by incubation with R)-ketamine, (S)-ketamine, BDS and BDS plus (S)-ketamine
Samples | % change in intracellular d-serine levels | % change in extracellular d-serine levels | ||
---|---|---|---|---|
Primary neuronal cells derived from cortex | Primary neuronal cells derived from hippocampus | Primary neuronal cells derived from cortex | Primary neuronal cells derived from hippocampus | |
Control | 100.00 | 100.00 | 100.00 | 100.00 |
(R)-Ket (1 μM) | −17.7 ± 2.5%* | −19.8 ± 2.6%* | −16.4 ± 3.2%* | −18.6 ± 1.9%* |
(S)-Ket (0.5 μM) | +22.1 ± 3.5%* | +24.6 ± 2.6%* | −19.5 ± 1.9%* | −18.7 ± 2.0%* |
BDS (50 μM) | +21.6 ± 1.9%* | +22.2 ± 1.9%* | −18.5 ± 2.8%* | −16.5 ± 1.6%* |
BDS + (S)-Ket | +47.2 ± 5.1%* | +45.3 ± 3.4%* | −44.1 ± 3.6%* | −42.5 ± 2.4%* |
Results are expressed as % change relative to concentrations measured in control experiments Each value represents the average ± SD (n = 3).
P < 0.05 as compared with the control cells.