Table 1.

The change in intracellular and extracellular d-serine concentrations in primary neuronal cells derived from rat cortex and hippocampus produced by incubation with R)-ketamine, (S)-ketamine, BDS and BDS plus (S)-ketamine

Samples	% change in intracellular d-serine levels		% change in extracellular d-serine levels
	Primary neuronal cells derived from cortex	Primary neuronal cells derived from hippocampus	Primary neuronal cells derived from cortex	Primary neuronal cells derived from hippocampus
Control	100.00	100.00	100.00	100.00
(R)-Ket (1 μM)	−17.7 ± 2.5%*	−19.8 ± 2.6%*	−16.4 ± 3.2%*	−18.6 ± 1.9%*
(S)-Ket (0.5 μM)	+22.1 ± 3.5%*	+24.6 ± 2.6%*	−19.5 ± 1.9%*	−18.7 ± 2.0%*
BDS (50 μM)	+21.6 ± 1.9%*	+22.2 ± 1.9%*	−18.5 ± 2.8%*	−16.5 ± 1.6%*
BDS + (S)-Ket	+47.2 ± 5.1%*	+45.3 ± 3.4%*	−44.1 ± 3.6%*	−42.5 ± 2.4%*

Results are expressed as % change relative to concentrations measured in control experiments Each value represents the average ± SD (n = 3).

^*P < 0.05 as compared with the control cells.