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. 2015 Jul 31;172(18):4546–4559. doi: 10.1111/bph.13239

Table 1.

The change in intracellular and extracellular d-serine concentrations in primary neuronal cells derived from rat cortex and hippocampus produced by incubation with R)-ketamine, (S)-ketamine, BDS and BDS plus (S)-ketamine

Samples % change in intracellular d-serine levels % change in extracellular d-serine levels
Primary neuronal cells derived from cortex Primary neuronal cells derived from hippocampus Primary neuronal cells derived from cortex Primary neuronal cells derived from hippocampus
Control 100.00 100.00 100.00 100.00
(R)-Ket (1 μM) −17.7 ± 2.5%* −19.8 ± 2.6%* −16.4 ± 3.2%* −18.6 ± 1.9%*
(S)-Ket (0.5 μM) +22.1 ± 3.5%* +24.6 ± 2.6%* −19.5 ± 1.9%* −18.7 ± 2.0%*
BDS (50 μM) +21.6 ± 1.9%* +22.2 ± 1.9%* −18.5 ± 2.8%* −16.5 ± 1.6%*
BDS + (S)-Ket +47.2 ± 5.1%* +45.3 ± 3.4%* −44.1 ± 3.6%* −42.5 ± 2.4%*

Results are expressed as % change relative to concentrations measured in control experiments Each value represents the average ± SD (n = 3).

*

P < 0.05 as compared with the control cells.