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. 2015 Aug 11;3(8):e12477. doi: 10.14814/phy2.12477

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© 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Arginine-derived hydroimidazolone residues and corresponding free adducts in plasma of SD and SDT rats at different ages. (A) Specimen chromatograms of MG-H1- and AP-free aducts in plasma of SDT rats at 8 and 24 weeks, (B) specimen chromatograms of G-H1-, CML-, and CEL-free adducts in plasma of SDT rats at 8 and 24 weeks, (C) MG-H1 residue, (D) MG-H1-free adduct, (E) G-H1 residue, and (F) G-H1-free adduct. Data are mean ± SEM (n = 4). Hollow bars, control SD rats; solid bars, SDT rats. Significance: statistical differences within group were evaluated using one-way analysis of variance (ANOVA), different letters represent the statistical differences at P < 0.05 among the means in each group by Dunnett’s test for multiple comparisons. *indicates significance of difference with respect to age-matched SD control rats by Student’s t-test, where one, two, and three symbols reflect *P < 0.05, **P < 0.01, and ***P < 0.001, respectively.