Table 1.
Characteristics of the SD and SDT rats at different ages
| Parameters | Rats | Age (weeks) | ||||
|---|---|---|---|---|---|---|
| 8 | 12 | 16 | 18 | 24 | ||
| Body weight (g) | SD | 218.7 ± 2.7 | 402.4 ± 6.6 | 500.6 ± 13.9 | 528.8 ± 13.7 | 595.2 ± 17.5 |
| SDT | 298.7 ± 2.6*** | 436.3 ± 1.8** | 499.0 ± 5.4 | 486.0 ± 4.9** | 432.3 ± 4.8*** | |
| Food intake (g/day) | SD | 23.4 ± 0.7 | 28.8 ± 0.4 | 28.8 ± 0.8 | 28.2 ± 0.4 | 26.6 ± 0.8 |
| SDT | 27.4 ± 0.5 | 27.4 ± 0.5 | 29.3 ± 0.6 | 34.8 ± 0.8*** | 41.7 ± 2.1*** | |
| Fasting BGL (mg/dL) | SD | 63.3 ± 1.8 | 62.8 ± 3.5 | 66.5 ± 3.4 | 68.1 ± 2.4 | 69.5 ± 2.6 |
| SDT | 65.3 ± 1.6 | 70.5 ± 2.3 | 58.3 ± 4.1 | 69.6 ± 3.9 | 99.1 ± 15.2*** | |
| Insulin (μU/mL) | SD | 84.4 ± 0.3 | 36.1 ± 7.5 | 38.2 ± 5.1 | 38.5 ± 6.3 | 37.2 ± 5.9 |
| SDT | 85.5 ± 1.0 | 62.4 ± 19.5 | 51.4 ± 5.9** | 53.2 ± 22.1 | 18.9 ± 2.0*** | |
| OGTT-AUC0–2 h (mg·h/dL) | SD | 211.7 ± 8.1 | 194.2 ± 6.5 | 199.7 ± 4.4 | – | 198.6 ± 7.8 |
| SDT | 330.8 ± 11.9*** | 445.6 ± 13.3*** | 527.7 ± 27.8*** | – | 765.3 ± 27.1*** | |
| HOMA-IR | SD | 13.1 ± 0.5 | 5.4 ± 0.9 | 6.2 ± 0.8 | 6.6 ± 1.1 | 5.7 ± 0.8 |
| SDT | 13.8 ± 0.4 | 10.5 ± 3.3 | 7.2 ± 0.5 | 8.6 ± 2.8 | 4.6 ± 0.8 | |
| Plasma AGEsa (μg/mL) | SD | 126 ± 35 | 103 ± 25 | 140 ± 21 | 186 ± 38 | 102 ± 18 |
| SDT | 134 ± 47 | 179 ± 79 | 113 ± 48 | 171 ± 25 | 98 ± 12 | |
Data are mean ± SEM (SD, n = 5; SDT, n = 4)
a
Plasma AGE levels were determined by a commercial AGE competitive ELISA kit. The dash (–) means no experiment performed.
Statistical differences were evaluated by Student’s t-test:
**
P < 0.01
***
P < 0.001 versus the age-matched control SD rats.