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. 2015 Aug 4;3(8):e12480. doi: 10.14814/phy2.12480

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© 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Anion exchange activity in human nasal epithelia cultured from patients with SLC26A4 mutations (DFNB4) and controls. (A) Representative tracings of anion exchange activity. (B) Measurements of anion exchange activity showing significantly increased activity following IL-13 treatment (10 ng/mL) in the controls (n = 4) but not in epithelia from patients harboring SLC26A4 mutations (DFNB4, n = 5). *indicates P < 0.05 compared with the PBS-treated cells.