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. 2015 Aug 26;3(8):e12482. doi: 10.14814/phy2.12482

Figure 1.

Figure 1

Cocaine modulates the permeability of L-LEC monolayers. (A) Permeability, as determined by the translocation of dextran particles through an L-LEC monolayer. Cells were serum-starved for 1 h and then incubated with cocaine (1, 10, 100 μmol/L) for 2 h before assessing permeability. Data represent the mean ± SD of three independent experiments. *P < 0.05 by ANOVA (analysis of variance test) for L-LECs incubated with cocaine versus control (0). (B) Cells were serum starved for 1 h and then incubated with cocaine alone (1, 10, 100 μmol/L) for 18 h, or pretreated with HIV-1 gp120 (200 ng/mL) for 2 h before incubating with cocaine, and proceeding as in (A). Data represent the mean ± SD of three independent experiments. *P < 0.05 by two-way ANOVA for L-LECs incubated with gp120 + cocaine versus cocaine alone.