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. 2015 Aug 13;3(8):e12508. doi: 10.14814/phy2.12508

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© 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Change in leg O₂ delivery with sildenafil (A), change in leg O₂ uptake with sildenafil (B) and the association between the change in leg O₂ delivery and the change in leg O₂ delivery with sildenafil (C) in young and older subjects performing knee-extensor exercise at 6 W, 12 W, and 40% W_max (19 ± 1 and 15 ± 1 W: young and older). Significant difference: *P < 0.05; significant difference from young within same condition: #P < 0.05.