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Difference between leg O2 delivery and leg O2 uptake (A) and association between change in leg O2 uptake and lactate release with sildenafil (B) in young and older subjects performing knee-extensor exercise at 6 W, 12 W, and 40% Wmax (19 ± 1 and 15 ± 1 W: young and older). Significant difference from young within same condition: #P < 0.05.
