Table 3. Adjusted linear regression coefficients and 95% confidence intervals of the association between adipokines and right ventricular structure and function.
Model 1: Adjusted for age, gender, race, height and weight. Model 2: Model 1 + education, systolic and diastolic blood pressure, total & HDL cholesterol, triglycerides, current smoking status and pack years, diabetes, waist & hip circumference, glucose, and currently taking statins or hypertension medication. Model 3: Model 2 + respective LV measure. Abbreviations: RV = right ventricle, LV = left ventricle, LVEDV = left ventricular end-diastolic volume, LVESV = left ventricular end-systolic volume, LVEF = left ventricular ejection fraction, LVSV = left ventricular stroke volume.
| Log Leptin, pg/mL | Log Resistin, pg/mL | Log TNF-α, pg/mL | Log Adiponectin, ng/mL | |
|---|---|---|---|---|
| RV End-Diastolic Mass (g) | ||||
| Model 1 | -0.34 (-0.56, -0.13) p = 0.002 | 0.03 (-0.42, 0.49) p = 0.88 | 0.06 (-0.26, 0.39) p = 0.70 | 0.06 (-0.28, 0.40) p = 0.73 |
| Model 2 | -0.30 (-0.51, -0.08) p = 0.008 | 0.02 (-0.44, 0.48) p = 0.95 | 0.11 (-0.22, 0.43) p = 0.52 | -0.09 (-0.45, 0.26) p = 0.62 |
| Model 2 + LV Mass | -0.13 (-0.34, 0.08) p = 0.21 | 0.05 (-0.38, 0.49) p = 0.81 | 0.01 (-0.30, 0.32) p = 0.94 | -0.15 (-0.48, 0.19) p = 0.39 |
| RV End-Diastolic Volume (mL) | ||||
| Model 1 | -4.14 (-5.58, -2.70) p < 0.001 | -1.82 (-4.90, 1.26) p = 0.25 | -0.80 (-3.00, 1.41) p = 0.48 | 1.81 (-0.49, 4.10) p = 0.12 |
| Model 2 | -3.81 (-5.25, -2.36) p < 0.001 | -1.77 (-4.84, 1.31) p = 0.26 | -0.53 (-2.71, 1.64) p = 0.63 | 0.90 (-1.49, 3.28) p = 0.46 |
| Model 2 + LVEDV | -0.75 (-1.81, 0.30) p = 0.16 | -0.49 (-2.68, 1.71) p = 0.66 | -0.30 (-1.85, 1.25) p = 0.71 | -0.30 (-2.00, 1.39) p = 0.73 |
| RV End-Systolic Volume (mL) | ||||
| Model 1 | -1.52 (-2.26, -0.78) p < 0.001 | -0.78 (-2.35, 0.80) p = 0.33 | 0.35 (-0.78, 1.48) p = 0.54 | -0.03 (-1.20, 1.15) p = 0.96 |
| Model 2 | -1.44 (-2.20, -0.69) p < 0.001 | -0.84 (-2.43, 0.76) p = 0.31 | 0.42 (-0.71, 1.54) p = 0.47 | -0.21 (-1.44, 1.03) p = 0.74 |
| Model 2 + LVESV | -0.66 (-1.33, 0.02) p = 0.05 | -0.93 (-2.34, 0.48) p = 0.20 | 0.11 (-0.89, 1.11) p = 0.83 | -0.83 (-1.93, 0.26) p = 0.14 |
| RV Stroke Volume (mL) | ||||
| Model 1 | -2.62 (-3.68, -1.55) p < 0.001 | -1.04 (-3.31, 1.23) p = 0.37 | -1.15 (-2.77, 0.48) p = 0.17 | 1.84 (0.15, 3.53) p = 0.03 |
| Model 2 | -2.36 (-3.43, -1.30) p < 0.001 | -0.93 (-3.19, 1.33) p = 0.42 | -0.95 (-2.54, 0.65) p = 0.25 | 1.10 (-0.65, 2.85) p = 0.22 |
| Model 2 + LVSV | -0.51 (-1.26, 0.25) p = 0.19 | 0.59 (-1.00, 2.17) p = 0.46 | -0.17 (-1.29, 0.95) p = 0.77 | 0.91 (-0.31, 2.14) p = 0.14 |
| RV Ejection Fraction (%) | ||||
| Model 1 | 0.05 (-0.36, 0.46) p = 0.82 | 0.22 (-0.65, 1.08) p = 0.63 | -0.37 (-0.99, 0.25) p = 0.24 | 0.43 (-0.22, 1.07) p = 0.19 |
| Model 2 | 0.06 (-0.36, 0.48) p = 0.78 | 0.27 (-0.61, 1.15) p = 0.55 | -0.35 (-0.97, 0.27) p = 0.27 | 0.38 (-0.30, 1.06) p = 0.27 |
| Model 2+ LVEF | -0.03 (-0.42, 0.35) p = 0.86 | 0.52 (-0.29, 1.33) p = 0.21 | -0.11 (-0.68, 0.47) p = 0.72 | 0.63 (0.00, 1.25) p = 0.05 |