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. Author manuscript; available in PMC: 2015 Sep 8.
Published in final edited form as: Gastroenterology. 2011 Jun 24;141(4):1439–1450. doi: 10.1053/j.gastro.2011.06.046

Figure 1. RB/p53 loss in the liver promotes cell cycle deregulation but not spontaneous tumor formation.

Figure 1

(A) Left, Ki67 staining in 14-day old livers. Right, percentage Ki67-positive hepatocytes (*p=0.03; ***p<0.0001). (B) Gene expression data for 14-day old, RB/p53-deficient mouse livers compared to wild-type livers. Left, changes in gene expression displayed as a heat map. Center, KEGG Pathway analysis with corresponding P-values and representative genes. Right, human liver samples (GSE6764) clustered based on average intensities of deregulated genes in RB/p53-deficient mouse livers. (C) Dissected 1-year old mouse livers, H&E and Ki67-stained sections. (D) Total protein lysates from 1-year old and 14-day old livers immunoblotted for the indicated proteins.