Table 4.
Reasons for patient discontinuing selected clinical trials of metformin and oral contraceptive pills in treatment of polycystic ovary syndrome
| Trial | Number of patient withdrawals, n | Reasons |
|---|---|---|
| Glintborg et al10 | M: 11 | M: pregnant (n=1), wanted OCP (n=2), depression (n=1), nausea (n=1), regrets (n=4), lost to follow-up (n=2) |
| M + OCP: 7 | M + OCP: nausea (n=3), regrets (n=2), lost to follow-up (n=2) | |
| OCP: 7 | OCP: wants pregnancy (n=2), side effects (n=3), lost to follow-up (n=2) | |
| Essah et al19 | M + OCP: 2 | M + OCP: lost to follow-up (n=1), moved away (n=1) |
| OCP + Pl: 2 | OCP + Pl: lost to follow-up (n=1), heavy menstrual bleeding (n=1) | |
| Panidis et al20 | Group A: 0 | – |
| Group B: 0 | ||
| Group C: 0 | ||
| Bilgir et al21 | M + OCP: 0 | – |
| OCP: 0 | ||
| Mitkov et al14 | M: 0 | – |
| M + OCP: 0 | ||
| Morin-Papunen et al12 | M: 2 | M: moved away (n=1), personal reasons (n=1) |
| OCP: 1 | OCP: headache and high blood pressure (n=1) | |
| Elter et al22 | M + OCP: 0 | – |
| OCP: 0 | ||
| Morin-Papunen et al23 | M: 5 | M: moved away (n=1), personal reasons (n=1), manifest diabetes mellitus (n=2), continuous nausea and diarrhea (n=1) |
| OCP: 2 | OCP: manifested diabetes mellitus (n=1), headache and high blood pressure (n=1) |
Abbreviations: M, metformin; OCP, oral contraceptive pill; Pl, placebo.