Table S1.
Medication class | Therapeutic chemicals | ATC codes | Marketing year in Taiwan |
---|---|---|---|
Oral bronchodilators | |||
Oral beta-2 agonists | Salbutamol | R03CC02 | 1974 |
Oral beta-2 agonists | Terbutaline | R03CC03 | 1979 |
Oral beta-2 agonists | Fenoterol | R03CC04 | 1979 |
Oral beta-2 agonists | Hexoprenaline | R03CC05 | 1982 |
Oral beta-2 agonists | Procaterol | R03CC08 | 1985 |
Oral beta-2 agonists | Trimetoquinol | R03CC09 | 1975 |
Oral beta-2 agonists | Bambuterol | R03CC12 | 1993 |
Oral beta-2 agonists | Clenbuterol | R03CC13 | 1988 |
Oral beta-2 agonists | Formoterol | R03CC91 | 1993 |
Oral xanthines | Theophylline | R03DA04 | 1972 |
Oral xanthines | Aminophylline | R03DA05 | 1970 |
Inhaled short-acting bronchodilators | |||
SABAs | Salbutamol | R03AC02 | 1989 |
SABAs | Terbutaline | R03AC03 | 1989 |
SABAs | Fenoterol | R03AC04 | 1992 |
SABAs | Hexoprenaline | R03AC06 | 1995 |
SAMAs | Ipratropium | R03BB01 | 1981 |
SABA/SAMA FDCsa | Fenoterol/Ipratropium | R03AK03 | 1986 |
SABA/SAMA FDCsa | Salbutamol/Ipratropium | R03AK04 | 2000 |
Inhaled long-acting bronchodilators | |||
LABAs | Salmeterol | R03AC12 | 1996 |
LABAs | Formoterol | R03AC13 | 2000 |
LABAs | Procaterol | R03AC16 | 1989 |
LABAs | Indacaterol | R03AC18 | 2010 |
LAMAs | Tiotropium | R03BB04 | 2003 |
LABA/ICS FDCs | Salmeterol/Fluticasone | R03AK06 | 2001 |
LABA/ICS FDCs | Formoterol/Budesonide | R03AK07 | 2001 |
Notes:
Prescriptions with SABA/SAMA FDCs were simultaneously assigned into use of SABAs and use of SAMAs.
Abbreviations: FDCs, fixed dose combinations; ICS, inhaled corticosteroids; LABAs, long-acting beta-2 agonists; LAMAs, long-acting muscarinic antagonists; SABAs, short-acting beta agonists; SAMAs, short-acting muscarinic antagonists.