Table 4.

THP-1 CC₅₀, Leishmania amazonensis (amastigote) IC₅₀, and selectivity index values of free SC, nanoemulsion, and amphotericin B 24 hours after preparation of the formulations

	SC	LP20	LP80	SP80	SP20	ANFB
CC50	44.47±6.60	8.95±6.62	ND	17.53±6.19	ND	>10
IC50	0.42±0.13	0.32±0.05	0.94±0.17	0.26±0.06	0.53±0.1	0.07±0.06
SI	105.88	27.97	ND	67.42	ND	>142

Note: CC₅₀ and IC₅₀ (µg·mL⁻¹) are expressed as mean ± standard deviation (n=3).

Abbreviations: CC₅₀, 50% cytotoxic concentration; IC₅₀, half maximal inhibitory concentration; ANFB, amphotericin B; LP20, soybean lecithin and polysorbate 20; LP80, soybean lecithin and polysorbate 80; ND, not determined; SC, (E)-3-(3-nitrophenyl)-1-(3,4,5-trimethoxyphenyl) prop-2-en-1-one; SI, selectivity index (CC₅₀/IC₅₀); SP20, sorbitan monooleate and polysorbate 20; SP80, sorbitan monooleate and polysorbate 80.