Table 3.
Immunohistochemical Results for hMLH1 and hMSH2 in the Screening of Microsatellite Instability Status
| Group | hMLH1 | hMSH2 | hMLH1-loss or hMSH2-loss | hMLH1-intact and hMSH2-intact | ||
|---|---|---|---|---|---|---|
|
|
|
|||||
| Intact | Loss | Intact | Loss | |||
| MSI-H (n=203) | 24 (11.8) | 179 (88.2) | 188 (92.6) | 15 (7.4) | 185 (91.1*) | 18 (8.9) |
| MSS (n=261) | 257 (98.5) | 4 (1.5) | 203 (100.0) | 0 | 4 (1.5) | 257 (98.5*) |
Data are presented as number (%).
MSI-H, microsatellite instability-high; MSS, microsatellite stable.
*
The values of 91.1% and 98.5% were the sensitivity and specificity, respectively, of the immunohistochemistry for the screening of the MSI phenotype of gastric cancers.