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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Trends Pharmacol Sci. 2015 Jun 9;36(9):568–578. doi: 10.1016/j.tips.2015.05.007

Figure 1.

Figure 1

The interaction and convergence of H2S and NO signaling pathways in endothelial function regulation. (1) NO may increase the expression of CSE [16], but inhibit the activity of CSE [19]. (2) NO may increase the cellular uptake of cystine [25]. (3) NO and H2S may form new molecules [26-28]. (4) NO makes its targets resistant to H2S so that H2S cannot modify the same targets as it does in the absence of NO [29]. (5) Under acidic condition, H2S induces the release of NO from nitrite or other NO derivatives. The solid arrow lines depict the stimulatory interactions whereas the dotted arrow lines indicate the inhibitory interactions.