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H2S signaling and endothelial dysfunction in cardiovascular diseases. Decreased endothelial H2S bioavailability contributes to the pathogenesis of all subtypes of EDF discussed. The phenotypes of EDF are numbered to facilitate the description. 1 - Barrier and anti-coagulation. 2 - Angiogenesis and self-repair. 3 - Synthesis and secretion. 4 -Endothelium-dependent vasorelaxation.
