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Noggin mRNA expression levels with increasing rhBMP-2 dose 24 hours after MC3T3-E1 were seeded on fibrin hydrogels. Values were normalized to MC3T3-E1 cells not treated with rhBMP-2 (0μg/mL rhBMP-2) noggin mRNA expression levels. Error bars denote standard error of the mean; *p < 0.05 vs. 0μg/mL BMP-2, **p < 0.05 between treatment group at next lower concentration.
