Table 1.
Demographic and clinical information.
| Characteristics | MAPa | ROSb | Total |
|---|---|---|---|
| N | 96 | 69 | 165 |
| Age at death, years (SD) | 90 (6) | 89 (7) | 90 (6) |
| Male, n (%) | 27 (28%) | 22 (32%) | 49 (30%) |
| Education, years (SD) | 14.2 (3) | 18 (4) | 16 (4) |
| Median time between last clinical evaluation and death, years | 0.77 | 0.77 | 0.77 |
| Antemortem clinical diagnosis, n (%) | |||
| - No cognitive impairment | 28 (29%) | 21 (30%) | 49 (30%) |
| - Mild cognitive impairment | 19 (20%) | 11 (16%) | 30 (18%) |
| - Alzheimer’s disease | 47 (49%) | 36 (52%) | 83 (50%) |
| - Other primary cause of dementia | 2 (2%) | 1 (2%) | 3 (2%) |
| Global cognition scorec, mean (SD) | −1.1 (1.2) | −1.1 (1.3) | −1.1 (1.2) |
| Episodic memory scorec, mean (SD) | −1.2 (1.3) | −0.9 (1.6) | −1.0 (1.4) |
| Semantic memory scorec, mean (SD) | −0.9 (1.4) | −1.1 (1.5) | −1.0 (1.4) |
| Working memory scorec, mean (SD) | −0.9 (1.1) | −1.1 (1.2) | −1.0 (1.1) |
| Perceptual speed scorec, mean (SD) | −1.3 (1.3) | −1.3 (1.2) | −1.3 (1.2) |
| Visuospatial ability scorec, mean (SD) | −0.9 (1.1) | −0.9 (1.1) | −0.8 (1.1) |
| Mini-mental State Examinationc (MMSE), mean (SD) | 19.9 (9.2) | 18.9 (10.2) | 19.5 (9.6) |
| Mini-mental State Examinationc (MMSE), median | 24 | 23 | 23 |
| Right hemisphere, n (%) | 49 (51%) | 32 (46%) | 81 (49%) |
| Postmortem interval to fixation, hours (SD) | 8 (5) | 9 (5) | 8 (5) |
| Postmortem interval to imaging, days (SD) | 48 (21) | 50 (20) | 49 (21) |
| MRI scanner, n (%) | |||
| - General Electric (3 Tesla) | 32 (33%) | 13 (19%) | 45 (27%) |
| - Philips (3 Tesla) | 34 (35%) | 31 (45%) | 65 (39%) |
| - Siemens (3 Tesla) | 30 (31%) | 25 (36%) | 55 (33%) |
a
Memory and Aging Project
b
Religious Orders Study
c
Proximate to death