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. Author manuscript; available in PMC: 2016 Oct 5.
Published in final edited form as: Brain Res. 2015 Jun 26;1622:127–136. doi: 10.1016/j.brainres.2015.06.018

Figure 1.

Figure 1

Time scales for lithium feeding and/or L-dopa/Carbidopa injection followed by chronic MPTP injection. Lithium was fed in food (0.127% LiCl) and L-dopa/Carbidopa was injected daily for 2 months (A). Abnormal involuntary movements (AIMs) were assessed via the hindlimb clasping test. The hindlimb clasping severity index (B) or average instances of clasping (C) were quantified. Pre-drug treatment (black bars) was compared with post-drug treatment (lined bars) and displayed as mean ± SEM: *: p<0.05, **: p<0.01 as assessed by unpaired t-test (n=6–9 in each group). Only significant comparison was displayed and not significant (n.s) was not labeled. Hindlimb clasping was counted for a 10 second period on 3 consecutive days and data combined for statistical analysis. Abb.: Pre: pre-drug treatment, Post: Post-drug treatment, Con: vehicle treated control, Sin: Sinemet (L-dopa/Carbidopa), Li: lithium feed.