Skip to main content
. 2015 Jun 20;4(9):593–604. doi: 10.1016/j.molmet.2015.06.006

Figure 1.

Figure 1

Genome editing methodologies which can be applied to human pluripotent stem cells. Homologous recombination (HR), or the more advanced tools such as zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs) or clustered regularly interspaced short palindromic repeat (CRISPR)/Cas system can be applied to human pluripotent stem cells (hPSCs) either to 1) create naturally occurring mutations or 2) repair a mutation to generate isogenic controls in hPSCs, to understand the function of a gene of interest.