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. 2015 Jun 25;4(9):619–630. doi: 10.1016/j.molmet.2015.06.007

Figure 1.

Figure 1

Low levels of LepR mRNA and receptor signalling in purified islet cells and whole islets, respectively. Amplification plot of LepR (red) or Ppia (cyclophilin, green) using mRNA purified from mouse islet (A) β (B) α or (C) δ cells or (D) hypothalamus. (E) Immunofluorescence staining of pStat3 in whole islets after treatment with either leptin (10 nM), TNF-α and IL1-β, or control non-treated islets. Data are representative of two further experiments. Scale bar 52.5 μm. See the Materials and Methods section for further details.