Figure 4.

Enhanced glucose-stimulated insulin secretion in Ins1CreLepR^KOfemales. (A) Blood glucose after IP injection of insulin in Ins1CreLepR^KO (square symbol) and LepR^F/F littermate controls (triangles) in males and females (n = 9–10 mice per genotype). (B) Plasma insulin levels after IP injection of glucose in males and females: Ins1CreLepR^KO, n = 10, LepR^F/F, n = 6. (C) Insulin secretion as assessed from isolated islet in response to glucose (LG = 3 mM, HG = 17 mM) and KCl (30 mM) in 30-week old female and male mice. n = 3 separate experiments involving 2–3 mice per genotype/experiment. Statistical analysis was performed using two-way ANOVA *P < 0.05.