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. 2015 Sep 9;35(36):12502–12517. doi: 10.1523/JNEUROSCI.1673-15.2015

Figure 3.

Figure 3.

Type II priming is not dependent on PKCε or local protein translation. Male rats that were treated with repeated intradermal administration of DAMGO (1 μg/h ×4) on the dorsum of the hindpaw received 1 week later an injection of PGE2 (100 ng) at the same site in the presence of vehicle (control, black bars), PKCε inhibitor (1 μg, gray bars), or the inhibitor of protein translation cordycepin (1 μg, white bars) administered 10 min before. Mechanical nociceptive threshold was evaluated 30 min and 4 h after PGE2. We observed no difference between the groups in the prolongation of the PGE2-induced hyperalgesia (F(4,30) = 0.72; p = 0.5861, two-way repeated-measures ANOVA followed by Bonferroni post hoc test), indicating that the neuroplasticity induced by previous repeated injection of DAMGO is not dependent on PKCε or local protein translation. n = 6 paws per group.