Table 7.
Regimens prescribed in case of nonresponse to treatment by paediatricians in Mumbai.
| Regimen prescribed | Number | Percent |
|---|---|---|
| Another regimen prescribed before investigating for multidrug-resistance (n = 23) | ||
| Repeat first regimen (HRZE) again | 1 | 4.3 |
| Addition of single drug | ||
| 2HRZES + 1HRE + 5HRE | 6 | 26.1 |
| E [HRZ]± | 1 | 4.3 |
| Clr [HRZ]± | 1 | 4.3 |
| Addition of two new drugs | ||
| HR + Eto + Cf | 2 | 8.7 |
| S + Of + [HRZE]± | 2 | 8.7 |
| Cf/Clr + S + [HRZE]± | 1 | 4.3 |
| HRES + Amk | 1 | 4.3 |
| HRZE + Clr + Lzd | 1 | 4.3 |
| Addition of three new drugs | ||
| Cs + Eto + Of | 1 | 4.3 |
| PAS + Of + E | 1 | 4.3 |
| Km + Eto + Lf | 1 | 4.3 |
| Addition of at least four new drugs | ||
| HR + PAS + Eto + Clr + Mfx + Km | 4 | 17.4 |
|
| ||
| Regimens prescribed for MDR-TB (n = 12) | ||
| At least four new drugs (i.e., not part of first regimen) including injectable and fluoroquinolone drugs# | 5 | 41.7 |
| As per results of drug sensitivity test (number and names of drugs not specified)$ | 4 | 33.3 |
| Addition of four new drugs but no injectable | 1 | 8.3 |
| Addition of only two new drugs | 2 | 16.7 |
±The paediatricians mentioned introducing new drug/s in this case but it was not clarified whether it was addition to or substitution of previous regimen (previous regimen in brackets), #regimen as per ISTC standard, $lack of information regarding number and names of drugs making it difficult to categorise into recommended or not recommended categories.
Amk: amikacin, Cf: ciprofloxacin, Clr: clarithromycin, Cs: cycloserine, E: ethambutol, Eto: ethionamide, H: isoniazid (INH), Km: kanamycin, Lzd: linezolid, Lf: levofloxacin, Mfx: moxifloxacin, Of: ofloxacin, Z: pyrazinamide, PAS: para-aminosalicylic acid, R: rifampicin, and S: streptomycin.