Table 4.
Associations between vascular risk factors, laboratory findings and age-related white matter changes.
| Age-related white matter changes | ||||
|---|---|---|---|---|
| Spearman's correlation |
Multiple linear regression |
|||
| ρ | P | β coefficient | P | |
| Age | 0.376 | < 0.001 | 0.372 | < 0.001 |
| Male | 0.041 | 0.683 | – | – |
| Body mass index (kg/m2) | 0.102 | 0.309 | – | – |
| Smoker | 0.025 | 0.805 | – | – |
| Hypertension | 0.263 | 0.008 | – | – |
| Diabetes mellitus | 0.192 | 0.053 | – | – |
| Dyslipidemia | − 0.020 | 0.843 | – | – |
| Atrial fibrillation | − 0.134 | 0.180 | – | – |
| Renal dysfunction | 0.082 | 0.414 | – | – |
| Systolic blood pressure (mm Hg) | 0.164 | 0.100 | – | – |
| Diastolic blood pressure (mm Hg) | 0.004 | 0.971 | – | – |
| History of stroke | 0.022 | 0.824 | – | – |
| History of coronary artery disease | 0.101 | 0.313 | – | – |
| Laboratory findings | ||||
| White blood cells (103/μl) | − 0.052 | 0.603 | – | – |
| HbA1c (%) | 0.215 | 0.030 | – | – |
| FBG (mg/dl) | 0.203 | 0.041 | – | – |
| LDL cholesterol (mg/dl) | − 0.039 | 0.701 | – | – |
| HDL cholesterol (mg/dl) | − 0.069 | 0.490 | – | – |
| TG (mg/dl) | 0.063 | 0.532 | – | – |
| eGFR (ml/min/1.73 m2) | − 0.155 | 0.121 | – | – |
| hs-CRP, log (ng/ml) | 0.043 | 0.670 | – | – |
| Telomere G-tail length (RLU/μg DNA) | − 0.309 | 0.002 | − 0.200 | 0.033 |
β coefficient means standardized partial regression coefficient.
FBG, fasting blood glucose; LDL, low-density lipoprotein; HDL, high-density lipoprotein; TG, triglycerides; eGFR, estimated glomerular filtration rate; RLU, relative light unit; DNA, deoxyribonucleic acid.