Table 2.

Differences in gray matter volumes for high-risk offspring versus healthy controls and ultra-high-risk offspring.

Regions	BA	Cluster sizea	MNI coordinatesb			T tests	PFWE-correctedc
X	Y	Z
HR offspring versus HC
Right OFC	11	90	6	62	− 20	4.10	0.023
Right cerebellum lobe	NA	935	8	− 54	− 6	4.41	0.029
UHR versus HR offspring
Right SFG	10	118	15	59	3	3.89	0.023
Right PCC	31	118	15	− 70	15	4.24	0.017
Left middle and inferior OG	31/30	187	− 48	− 79	0	4.19	0.033
Left SPC	7	59	− 15	− 73	39	3.78	0.047

Abbreviations: HR, high-risk; HC, healthy controls; BA, Brodmann's areas; OFC, orbitofrontal cortex; SFG, superior frontal gyrus; PCC, posterior cingulate cortex; OG, occipital gyrus; and SPC, superior parietal cortex.

^aStatistics at voxel-level set to a minimum uncorrected threshold of p < 0.001, k > 50 voxels.

^bMontreal Neurological institute coordinates in millimeters.

^cFamily-wise error correction for multiple comparisons.