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The Markov State Model of PKA-RIα R2C2 holoenzyme. A representation of MSM states for the activation of PKA-RIα R2C2 holoenzyme by cAMP first published in JBC (Boras et al., 2014). The red arrows represent the dominant pathway during activation. The two R- and C-subunits are identical but for simplicity of naming the first R-subunit to bind C-subunit is named R, while the first R-subunit to bind cAMP is R′.
