Table 3.
Incidence rate of first decline in eGFR in metformin new users
| Baseline eGFR | Northern Denmark |
UK |
||||||
|---|---|---|---|---|---|---|---|---|
| N (denominator) | Count (first decline in eGFR) | Person-years (to first decline in eGFR) | Incidence rate (95% CI), per 100 person-years | N (denominator) | Count (first decline in eGFR) | Person-years (to first decline in eGFR) | Incidence rate (95% CI), per 100 person-years | |
| Total | 22 728 | 3434 | 69 792 | 4.92 (4.76 to 5.09) | 101 992 | 27 325 | 365 208 | 7.48 (7.39 to 7.57) |
| ≥60 | 20 677 | 2695 | 65 088 | 4.14 (3.99 to 4.30) | 76 304 | 18 936 | 275 873 | 6.86 (6.77 to 6.96) |
| 45–59 | 1576 | 583 | 3857 | 15.12 (13.94 to 16.40) | 20 648 | 7089 | 73 832 | 9.60 (9.38 to 9.83) |
| 30–44 | 410 | 143 | 761 | 18.80 (15.96 to 22.15) | 4620 | 1266 | 14 637 | 8.65 (8.18 to 9.14) |
| 15–29 | 61 | 13 | 82 | 15.79 (9.17 to 27.19) | 408 | 34 | 866 | 3.93 (2.76 to 5.42) |
| <15 | 4 | . | 4 | – | 12 | 0 | 11 | NA |
eGFR, estimated glomerular filtration rate; NA, not available/applicable.