Table 2.
SNP | Gene | Control MAF | Vitiligo | Early onset | Late onset | Familial | Sporadic | Extent < 10% | Extent ≥ 10% | Active | Stable | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MAF | P-value | MAF | P-value | MAF | P-value | MAF | P-value | MAF | P-value | MAF | P-value | MAF | P-value | MAF | P-value | MAF | P-value | |||
rs2247421 | 0.354 | 0.338 | 0.6434 | 0.329 | 0.6583 | 0.342 | 0.7544 | 0.319 | 0.56 | 0.343 | 0.7765 | 0.359 | 0.9097 | 0.316 | 0.4009 | 0.344 | 0.7934 | 0.326 | 0.6039 | |
rs4140967 | 0.317 | 0.300 | 0.6069 | 0.288 | 0.5876 | 0.305 | 0.7525 | 0.292 | 0.6562 | 0.301 | 0.6666 | 0.309 | 0.8452 | 0.291 | 0.5508 | 0.298 | 0.6131 | 0.305 | 0.8184 | |
rs10776482 | TLR10 | 0.135 | 0.174 | 0.1312 | 0.141 | 0.8811 | 0.188 | 0.0727 | 0.206 | 0.1116 | 0.165 | 0.2962 | 0.129 | 0.8524 | 0.220 | 0.0134 | 0.170 | 0.2306 | 0.183 | 0.2399 |
rs7694115 | TLR10 | 0.359 | 0.431 | 0.0446 | 0.402 | 0.4472 | 0.443 | 0.0387 | 0.457 | 0.1089 | 0.421 | 0.1193 | 0.464 | 0.0214 | 0.396 | 0.4323 | 0.405 | 0.2541 | 0.488 | 0.0226 |
rs7660429 | TLR10 | 0.235 | 0.285 | 0.1147 | 0.275 | 0.4332 | 0.289 | 0.1306 | 0.292 | 0.2896 | 0.281 | 0.1994 | 0.353 | 0.0045* | 0.216 | 0.641 | 0.263 | 0.4312 | 0.333 | 0.0506 |
rs12233670 | 0.131 | 0.153 | 0.3775 | 0.100 | 0.4323 | 0.175 | 0.125 | 0.157 | 0.5452 | 0.153 | 0.4235 | 0.138 | 0.8379 | 0.169 | 0.2458 | 0.147 | 0.5678 | 0.167 | 0.3725 | |
rs10005625 | 0.005 | 0 | 0.244 | 0 | 0.5252 | 0 | 0.3286 | 0 | 0.5516 | 0 | 0.3188 | 0 | 0.4065 | 0 | 0.4133 | 0 | 0.3311 | 0 | 0.5202 | |
rs5743810 | TLR6 | 0.387 | 0.383 | 0.9257 | 0.476 | 0.1217 | 0.344 | 0.2863 | 0.333 | 0.3796 | 0.405 | 0.6421 | 0.370 | 0.7116 | 0.397 | 0.8196 | 0.384 | 0.9546 | 0.381 | 0.9218 |
rs6531668 | 0.428 | 0.427 | 0.9809 | 0.549 | 0.0385 | 0.375 | 0.1948 | 0.347 | 0.1897 | 0.460 | 0.4265 | 0.420 | 0.8709 | 0.434 | 0.899 | 0.417 | 0.7842 | 0.451 | 0.6885 | |
rs6531670 | 0.449 | 0.419 | 0.4482 | 0.348 | 0.1174 | 0.451 | 0.9618 | 0.538 | 0.2147 | 0.380 | 0.1166 | 0.436 | 0.8035 | 0.400 | 0.3587 | 0.410 | 0.3911 | 0.439 | 0.8793 | |
rs1992253 | 0.038 | 0.016 | 0.0885 | 0.014 | 0.2821 | 0.017 | 0.1609 | 0.016 | 0.3606 | 0.016 | 0.1387 | 0.016 | 0.2234 | 0.015 | 0.1974 | 0.017 | 0.1797 | 0.012 | 0.2442 | |
rs4585282 | TLR2 | 0.008 | 0.015 | 0.3593 | 0.025 | 0.1572 | 0.011 | 0.7506 | 0.015 | 0.565 | 0.015 | 0.3959 | 0.021 | 0.1746 | 0.008 | 0.9788 | 0.005 | 0.7068 | 0.036 | 0.0264 |
rs7694512 | TLR2 | 0.359 | 0.369 | 0.7681 | 0.300 | 0.2988 | 0.399 | 0.3212 | 0.343 | 0.7893 | 0.378 | 0.6389 | 0.400 | 0.3641 | 0.336 | 0.6198 | 0.326 | 0.4122 | 0.464 | 0.0613 |
rs13123230 | TLR2 | 0.391 | 0.379 | 0.7193 | 0.325 | 0.2506 | 0.401 | 0.8125 | 0.357 | 0.577 | 0.385 | 0.8712 | 0.407 | 0.7319 | 0.348 | 0.3576 | 0.339 | 0.1945 | 0.465 | 0.1919 |
rs1339 | RNF175 | 0.262 | 0.260 | 0.9675 | 0.230 | 0.5552 | 0.273 | 0.7578 | 0.266 | 0.9433 | 0.256 | 0.8729 | 0.262 | 0.9927 | 0.258 | 0.9422 | 0.250 | 0.7609 | 0.284 | 0.6815 |
rs2289318 | RNF175 | 0.253 | 0.257 | 0.8998 | 0.317 | 0.2166 | 0.232 | 0.5493 | 0.229 | 0.6516 | 0.270 | 0.6439 | 0.239 | 0.7319 | 0.276 | 0.5837 | 0.268 | 0.6762 | 0.233 | 0.6782 |
rs11721827 | TLR3 | 0.199 | 0.196 | 0.9199 | 0.171 | 0.5626 | 0.207 | 0.8189 | 0.167 | 0.5294 | 0.198 | 0.9713 | 0.246 | 0.2359 | 0.145 | 0.1635 | 0.189 | 0.7641 | 0.214 | 0.7625 |
rs6552950 | TLR3 | 0.266 | 0.226 | 0.2106 | 0.244 | 0.678 | 0.218 | 0.1912 | 0.271 | 0.9164 | 0.206 | 0.0967 | 0.217 | 0.2419 | 0.234 | 0.4645 | 0.225 | 0.2745 | 0.226 | 0.4409 |
rs4608848 | 0.371 | 0.409 | 0.2841 | 0.450 | 0.1705 | 0.392 | 0.6016 | 0.472 | 0.0942 | 0.385 | 0.7209 | 0.449 | 0.0875 | 0.368 | 0.9431 | 0.400 | 0.4701 | 0.429 | 0.3068 | |
rs1519309 | 0.306 | 0.281 | 0.4544 | 0.288 | 0.7363 | 0.278 | 0.4653 | 0.250 | 0.3275 | 0.295 | 0.7707 | 0.290 | 0.7108 | 0.272 | 0.4359 | 0.271 | 0.3639 | 0.302 | 0.946 | |
rs10759932 | TLR4 | 0.196 | 0.196 | 0.9954 | 0.229 | 0.5192 | 0.181 | 0.6712 | 0.217 | 0.7025 | 0.188 | 0.8277 | 0.173 | 0.5674 | 0.221 | 0.5543 | 0.188 | 0.815 | 0.214 | 0.7172 |
rs5030728 | TLR4 | 0.287 | 0.222 | 0.0563 | 0.203 | 0.125 | 0.231 | 0.1586 | 0.129 | 0.0077* | 0.256 | 0.4228 | 0.277 | 0.8198 | 0.169 | 0.0082* | 0.228 | 0.1355 | 0.206 | 0.1556 |
rs5935436 | TLR7 | 0.079 | 0.048 | 0.0977 | 0.061 | 0.5662 | 0.043 | 0.0881 | 0.057 | 0.5162 | 0.045 | 0.1103 | 0.074 | 0.8313 | 0.022 | 0.0192 | 0.048 | 0.1487 | 0.049 | 0.3313 |
rs179020 | TLR7 | 0.225 | 0.361 | 8.5E-5* | 0.226 | 0.9826 | 0.416 | 1.5E-6* | 0.293 | 0.2365 | 0.378 | 8.7E-5* | 0.366 | 0.0014 | 0.356 | 0.004 | 0.342 | 0.0027 | 0.406 | 0.0012 |
rs179013 | TLR7 | 0.243 | 0.317 | 0.0208 | 0.305 | 0.2214 | 0.321 | 0.0291 | 0.319 | 0.1548 | 0.319 | 0.0326 | 0.310 | 0.0979 | 0.324 | 0.051 | 0.328 | 0.019 | 0.291 | 0.3339 |
rs179008 | TLR7 | 0.258 | 0.326 | 0.041 | 0.325 | 0.2038 | 0.326 | 0.0705 | 0.309 | 0.3689 | 0.330 | 0.0517 | 0.329 | 0.0915 | 0.323 | 0.1408 | 0.341 | 0.0293 | 0.293 | 0.5055 |
rs10127190 | TLR7 | 0.005 | 0.004 | 0.7874 | 0 | 0.5252 | 0.005 | 0.9723 | 0 | 0.5516 | 0.005 | 1.0 | 0.007 | 0.7518 | 0 | 0.4133 | 0 | 0.3311 | 0.012 | 0.4391 |
rs850632 | 0.264 | 0.264 | 0.9861 | 0.305 | 0.4323 | 0.247 | 0.6479 | 0.292 | 0.6149 | 0.248 | 0.6448 | 0.271 | 0.8563 | 0.257 | 0.8747 | 0.255 | 0.8104 | 0.286 | 0.6721 | |
rs179003 | 0.188 | 0.215 | 0.3799 | 0.243 | 0.2601 | 0.202 | 0.6825 | 0.219 | 0.5564 | 0.216 | 0.4165 | 0.189 | 0.9961 | 0.242 | 0.1801 | 0.235 | 0.1756 | 0.167 | 0.6553 |
P ≤ 0.05 bolded;
P ≤ 0.05 after 10 000 permutations.