Density distribution of correlation of the five initial genes and their paired miRNAs for tumor and normal samples
Pearson correlation was calculated for all possible pair combinations of FGFR3, HRAS, RB1, TSC1, and TP53 and 1046 miRNAs listed in the BLCA dataset downloaded from TCGA. Targeting relationship was then predicted using databases including TargetProfiler, TargetScan, and miRanda. The distribution of the miRNA–mRNA correlation values of the prediction results by three databases is presented for tumor samples (A) and normal samples (B).