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. 2015 Sep 9;5:13855. doi: 10.1038/srep13855

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Copyright © 2015, Macmillan Publishers Limited

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After differentiating monocytes for 12 days, monocyte-derived macrophages were labeled with CellTracker blue then co-cultured with GFP-expressing MCF-7 breast cancer cells and allowed to invade through a collagen I gel. Confocal microscope was used to image the height of the gel and quantify the number of cells that invaded past 30 μm. (A) GFP-expressing MCF7 cells do not significantly invade into the collagen I gel without the MDMs, but (B) co-culture with the MDMs increases the invasion of the GFP-tagged MCF-7 cells.