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. 2015 Sep 9;5:13850. doi: 10.1038/srep13850

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Copyright © 2015, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The scheme includes four steps. Firstly, differentially expressed lncRNAs and coding genes in neonatal brains following hypoxic-ischemic brain injury compared with sham control brains were identified via microarray analysis. Then, bioinformatics analysis, including GO and KEGG pathway enrichment and CNC network, were performed for speculating the correlation between lncRNAs and coding genes. Subsequently, we utilized qRT-PCR to validate the microarray results. Finally, lncRNA function was analyzed by lncRNA knockdown and subsequent CCK8 and TUNEL detection.