Fig. 1.

Histopathology and immunohistochemical staining. (A) Low power (20 ×) H&E stained section from the cone biopsy at 8 o'clock showing a densely cellular NEC composed of small cells with high nuclear cytoplasmic ratio invading to a depth of 3.5 mm, extending to the ectocervical margin of resection, and involving lymphovascular spaces. (B) High power (400 ×) image of tumor showing dense cellularity, high nuclear cytoplasmic ratio, and scant cytoplasm with strong diffuse immunoreactivity for synaptophysin, and (C) adjacent high power (400 ×) image demonstrating strong cytoplasmic staining for chromogranin.