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. 2015 May 26;125(7):2579–2591. doi: 10.1172/JCI77347

Figure 3. Stromal cell–derived IL-33 engages ST2 signaling on both the stromal and the hematopoietic compartment to induce MPN-like disease.

Figure 3

(A) Contribution of IL-33 and IL-33/ST2 signaling in radio-resistant cells. (B) Contribution of IL-33/ST2 signaling in radio-sensitive cells. Survival curves and disease activity index are shown for the indicated groups of BM chimeric mice. Pooled data from 2 independent experiments are represented each for (A) styx→WT (n = 14), styx→St2–/– (n = 8), styx→Il33–/– (n = 9), and (B) styx→WT (n = 9), styx St2–/–→styx St2–/– (n = 10), and styx St2–/–→WT (n = 10). Log-rank (Mantel-Cox) test was used. † indicates euthanasia of animals. ***P < 0.001; ****P < 0.0001.