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. 2015 Sep;14(9):2375–2393. doi: 10.1074/mcp.M114.046813

Table I. List of 333 regulated proteins in 4 PMI patient samples using iTRAQ workflow.

Uniprot accession number Gene symbol Protein name Log2 iTRAQ ratio (average of 4 PMI patients)
Moderated F-test p valuea Clusterb
10min vs. BL 1hr vs. BL 4hr vs. BL
Q9UPZ6 THSD7A Thrombospondin type-1 domain-containing protein 7A 0.907 0.755 0.022 2.06E-05 1
Q9C0I4 THSD7B Thrombospondin type-1 domain-containing protein 7B 0.669 0.574 0.040 8.12E-03 1
Q8IUX7 AEBP1 Adipocyte enhancer-binding protein 1 1.215 0.868 −0.082 1.17E-03 1
Q8N436 CPXM2 Inactive carboxypeptidase-like protein X2 1.986 1.447 −0.234 2.28E-02 1
Q02818 NUCB1 Nucleobindin-1 0.713 0.571 −0.050 1.09E-02 1
P05164–3 MPO Isoform H7 of Myeloperoxidase 0.924 0.760 0.116 1.21E-04 1
P19801–2 AOC1 Isoform 2 of Amiloride-sensitive amine oxidase [copper-containing] 1.383 1.298 0.155 2.06E-05 1
P02549 SPTA1 Spectrin alpha chain, erythrocytic 1 0.408 0.405 0.209 6.68E-03 1
Q12906–7 ILF3 Isoform 7 of Interleukin enhancer-binding factor 3 0.180 0.169 0.054 4.45E-02 1
P11150 LIPC Hepatic triacylglycerol lipase 1.186 1.347 0.150 5.93E-05 1
P19883 FST Follistatin 1.187 0.944 0.019 3.59E-05 1
P08294 SOD3 Extracellular superoxide dismutase [Cu-Zn] 0.702 0.579 0.011 5.07E-03 1
Q8N474 SFRP1 Secreted frizzled-related protein 1 1.372 0.901 0.081 8.71E-05 1
P80303–2 NUCB2 Isoform 2 of Nucleobindin-2 0.518 0.448 0.133 1.02E-02 1
P21741 MDK Midkine 2.341 1.655 0.208 1.21E-04 1
P10646 TFPI Tissue factor pathway inhibitor 0.474 0.523 −0.025 4.28E-02 1
O95631 NTN1 Netrin-1 0.799 0.641 0.121 8.03E-04 1
P25940 COL5A3 Collagen alpha-3(V) chain 0.547 0.365 0.019 3.96E-02 1
P21246 PTN Pleiotrophin 2.209 1.906 0.338 1.11E-04 1
P02776 PF4 Platelet factor 4 1.308 1.251 0.413 2.81E-02 1
P10720 PF4V1 Platelet factor 4 variant 1.261 1.149 0.415 2.09E-02 1
P20827 EFNA1 Ephrin-A1 0.360 0.355 0.045 1.83E-02 1
Q9BY76 ANGPTL4 Angiopoietin-related protein 4 0.609 0.397 0.229 2.50E-02 1
Q15109–3 AGER Isoform 3 of Advanced glycosylation end product-specific receptor 0.553 0.366 −0.040 2.97E-02 1
O43508 TNFSF12 Tumor necrosis factor ligand superfamily member 12 0.714 0.467 −0.064 4.95E-02 1
P02788 LTF Lactotransferrin 0.329 0.210 0.140 2.09E-02 1
Q99584 S100A13 Protein S100-A13 1.131 1.003 0.126 9.07E-03 1
P18827 SDC1 Syndecan-1 0.312 0.297 0.175 5.58E-03 1
O95969 SCGB1D2 Secretoglobin family 1D member 2 1.302 0.359 0.369 3.40E-02 1
E7EN11 CACNB4 Voltage-dependent l-type calcium channel subunit beta-4 0.497 0.377 0.333 2.65E-02 1
P04040 CAT Catalase 0.090 0.312 0.360 3.96E-02 2
Q13228–4 SELENBP1 Isoform 4 of Selenium-binding protein 1 0.050 0.246 0.294 4.76E-02 2
P00558 PGK1 Phosphoglycerate kinase 1 0.172 0.643 0.709 4.54E-04 2
P48147 PREP Prolyl endopeptidase 0.113 0.394 0.408 2.75E-03 2
P07951–2 TPM2 Isoform 2 of Tropomyosin beta chain 0.338 0.549 0.517 6.83E-03 2
P07951 TPM2 Tropomyosin beta chain 0.316 0.510 0.462 2.70E-02 2
P06733 ENO1 Alpha-enolase 0.112 0.262 0.340 1.81E-02 2
P02144 MB Myoglobin 0.790 1.939 1.506 2.03E-04 2
P68082 MB Myoglobin 0.710 1.970 1.533 5.12E-04 2
P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0.141 0.729 0.729 2.22E-02 2
P60174 TPI1 Triosephosphate isomerase 0.345 1.067 0.893 8.03E-04 2
P60174–4 TPI1 Isoform 4 of Triosephosphate isomerase 0.327 1.110 0.923 1.17E-03 2
P63104 YWHAZ 14–3-3 protein zeta/delta 0.241 0.433 0.458 8.41E-03 2
P31946–2 YWHAB Isoform Short of 14–3-3 protein beta/alpha 0.157 0.388 0.313 3.94E-03 2
Q04917 YWHAH 14–3-3 protein eta 0.195 0.422 0.483 1.52E-03 2
P27348 YWHAQ 14–3-3 protein theta 0.156 0.368 0.394 9.83E-04 2
P31947 SFN 14–3-3 protein sigma 0.191 0.427 0.542 3.55E-04 2
P28838 LAP3 Cytosol aminopeptidase 0.166 0.562 0.633 2.12E-02 2
E7EQ12 CAST Calpastatin 0.153 0.434 0.554 2.26E-03 2
P15259 PGAM2 Phosphoglycerate mutase 2 0.294 1.157 1.388 2.08E-04 2
P61158 ACTR3 Actin-related protein 3 0.154 0.248 0.255 1.66E-02 2
P05413 FABP3 Fatty acid-binding protein, heart 0.615 1.831 1.851 1.13E-04 2
P40926 MDH2 Malate dehydrogenase, mitochondrial 0.747 1.976 1.374 1.21E-04 2
Q5JRA6 MIA3 Melanoma inhibitory activity protein 3 0.308 0.506 0.443 6.73E-04 2
P23526 AHCY Adenosylhomocysteinase 0.182 0.477 0.435 1.93E-03 2
P15121 AKR1B1 Aldose reductase 0.276 1.009 0.778 8.03E-04 2
P35237 SERPINB6 Serpin B6 0.050 0.225 0.204 1.08E-02 2
Q5T4U5 ACADM Acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain, isoform CRA a 0.452 1.138 1.259 1.17E-03 2
O15143 ARPC1B Actin-related protein 2/3 complex subunit 1B 0.145 0.291 0.262 3.00E-02 2
P07738 BPGM Bisphosphoglycerate mutase 0.136 0.337 0.327 2.26E-02 2
Q9HC38–2 GLOD4 Isoform 2 of Glyoxalase domain-containing protein 4 0.059 0.323 0.342 2.86E-02 2
Q9HC38 GLOD4 Glyoxalase domain-containing protein 4 0.059 0.337 0.342 3.19E-02 2
B7Z403 GLOD4 Glyoxalase domain-containing protein 4 0.066 0.324 0.329 3.00E-02 2
P61160 ACTR2 Actin-related protein 2 0.149 0.248 0.276 2.15E-02 2
P10768 ESD S-formylglutathione hydrolase 0.141 0.550 0.610 1.23E-03 2
Q8N142 ADSSL1 Adenylosuccinate synthetase isozyme 1 0.125 1.054 1.038 1.72E-02 2
Q9UJ70 NAGK N-acetyl-d-glucosamine kinase 0.048 0.261 0.202 2.65E-02 2
P54727 RAD23B UV excision repair protein RAD23 homolog B 0.102 0.299 0.389 2.26E-03 2
P30086 PEBP1 Phosphatidylethanolamine-binding protein 1 0.256 0.877 0.553 5.07E-03 2
Q99497 PARK7 Protein DJ-1 0.059 0.439 0.511 4.01E-03 2
Q13011 ECH1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 0.300 1.433 1.186 1.99E-03 2
P00492 HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 0.123 0.355 0.365 1.06E-03 2
Q32Q12 NME1-NME2 Nucleoside diphosphate kinase 0.112 0.447 0.305 2.81E-03 2
P15531–2 NME1 Isoform 2 of Nucleoside diphosphate kinase A 0.114 0.430 0.359 2.75E-03 2
F6XY72 NME1-NME2 Protein NME1-NME2 0.078 0.456 0.269 1.53E-03 2
Q9UL46 PSME2 Proteasome activator complex subunit 2 0.106 0.316 0.342 4.57E-02 2
Q16836–2 HADH Isoform 2 of Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial 0.542 1.898 1.485 2.03E-04 2
Q13642–4 FHL1 Isoform 4 of Four and a half LIM domains protein 1 0.235 0.841 0.642 1.98E-04 2
P62805 HIST1H4A Histone H4 0.631 1.166 1.441 7.14E-05 2
Q8TDQ7 GNPDA2 Glucosamine-6-phosphate isomerase 2 0.097 0.234 0.291 1.57E-02 2
P46926 GNPDA1 Glucosamine-6-phosphate isomerase 1 0.154 0.417 0.445 4.17E-03 2
Q96DG6 CMBL Carboxymethylenebutenolidase homolog 0.160 0.833 0.749 2.21E-02 2
P59998 ARPC4 Actin-related protein 2/3 complex subunit 4 0.175 0.415 0.350 2.12E-02 2
P00441 SOD1 Superoxide dismutase [Cu-Zn] 0.168 0.629 0.448 2.12E-02 2
P49247 RPIA Ribose-5-phosphate isomerase 0.071 0.215 0.200 2.04E-02 2
P02689 PMP2 Myelin P2 protein 0.296 0.822 0.824 1.98E-02 2
Q96C23 GALM Aldose 1-epimerase 0.047 0.381 0.472 4.08E-02 2
P29218 IMPA1 Inositol monophosphatase 1 0.174 0.679 0.874 8.74E-04 2
P30042 C21orf33 ES1 protein homolog, mitochondrial 0.409 1.330 1.248 1.11E-03 2
Q15631 TSN Translin 0.164 0.334 0.367 5.07E-03 2
O00764 PDXK Pyridoxal kinase 0.113 0.800 0.780 2.49E-02 2
P63208 SKP1 S-phase kinase-associated protein 1 0.095 0.434 0.352 2.38E-02 2
O15145 ARPC3 Actin-related protein 2/3 complex subunit 3 0.160 0.350 0.326 2.36E-02 2
Q04760 GLO1 Lactoylglutathione lyase 0.287 0.742 0.523 2.29E-03 2
P06734 FCER2 Low affinity immunoglobulin epsilon Fc receptor 0.130 0.184 0.188 4.45E-02 2
P07108 DBI Acyl-CoA-binding protein 0.221 0.688 0.523 1.18E-02 2
P50461 CSRP3 Cysteine and glycine-rich protein 3 0.359 1.504 1.617 5.93E-05 2
U3KQK0 HIST1H2BN Histone H2B 0.522 1.251 1.556 2.06E-05 2
P33778 HIST1H2BB Histone H2B type 1-B 0.582 1.259 1.606 4.41E-05 2
Q99880 HIST1H2BL Histone H2B type 1-L 0.536 1.269 1.573 2.06E-05 2
P30048 PRDX3 Thioredoxin-dependent peroxide reductase, mitochondrial 0.085 0.882 1.013 7.43E-03 2
O95861–2 BPNT1 Isoform 2 of 3′(2′),5′-bisphosphate nucleotidase 1 0.092 0.478 0.458 1.41E-03 2
O75347 TBCA Tubulin-specific chaperone A 0.020 0.296 0.261 4.86E-02 2
P84243 H3F3A Histone H3.3 0.584 1.241 1.502 2.03E-04 2
P68431 HIST1H3A Histone H3.1 0.570 1.181 1.411 5.93E-05 2
Q71DI3 HIST2H3A Histone H3.2 0.648 1.256 1.506 2.08E-04 2
Q5TEC6 HIST2H3PS2 Histone H3 0.467 1.084 1.322 7.20E-04 2
P10644 PRKAR1A cAMP-dependent protein kinase type I-alpha regulatory subunit 0.105 0.311 0.321 2.12E-02 2
Q9NR45 NANS Sialic acid synthase 0.106 0.312 0.388 1.61E-02 2
Q9H0R4 HDHD2 Haloacid dehalogenase-like hydrolase domain-containing protein 2 0.179 0.619 0.773 5.11E-03 2
P61970 NUTF2 Nuclear transport factor 2 0.044 0.343 0.218 3.53E-02 2
Q9NVS9 PNPO Pyridoxine-5′-phosphate oxidase 0.182 0.407 0.419 3.45E-02 2
Q12765–2 SCRN1 Isoform 2 of Secernin-1 0.092 0.234 0.282 2.63E-02 2
Q6FI13 HIST2H2AA3 Histone H2A type 2-A 0.665 1.483 1.843 3.17E-04 2
Q7L7L0 HIST3H2A Histone H2A type 3 0.667 1.497 1.843 2.99E-04 2
P0C0S5 H2AFZ Histone H2A.Z 0.799 1.522 1.934 2.79E-03 2
P23297 S100A1 Protein S100-A1 0.977 1.678 1.967 6.15E-04 2
O15511 ARPC5 Actin-related protein 2/3 complex subunit 5 0.209 0.283 0.324 2.76E-02 2
P35754 GLRX Glutaredoxin-1 0.040 0.316 0.279 2.24E-03 2
Q9NRX4 PHPT1 14 kDa phosphohistidine phosphatase 0.144 0.450 0.296 1.66E-02 2
Q99729 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 0.117 0.240 0.264 3.18E-02 2
Q14061 COX17 Cytochrome c oxidase copper chaperone 0.858 1.712 1.342 2.08E-04 2
Q7Z4H3 HDDC2 HD domain-containing protein 2 0.089 0.569 0.518 2.51E-03 2
Q99471 PFDN5 Prefoldin subunit 5 0.265 0.605 0.500 4.92E-03 2
P14621 ACYP2 Acylphosphatase-2 0.198 0.696 0.607 8.97E-03 2
U3KQL2 ACYP2 Acylphosphatase-2 0.212 0.570 0.520 7.64E-03 2
Q07507 DPT Dermatopontin 0.454 0.749 0.654 2.27E-02 2
B7Z4W5 CCBL1 Cysteine conjugate-beta lyase cytoplasmic (Glutamine transaminase K, kyneurenine aminotransferase), isoform CRA b −0.037 0.687 0.810 3.24E-02 2
Q9UHP9 SMPX Small muscular protein 0.464 0.643 0.659 9.28E-03 2
P07919 UQCRH Cytochrome b-c1 complex subunit 6, mitochondrial 0.674 1.897 1.652 9.22E-03 2
P49789 FHIT Bis(5′-adenosyl)-triphosphatase 0.050 1.026 0.608 2.49E-02 2
Q0VDG4 SCRN3 Secernin-3 0.246 0.433 0.566 2.79E-03 2
Q86YS3 RAB11FIP4 Rab11 family-interacting protein 4 0.208 0.811 0.652 9.67E-03 2
Q9ULP9 TBC1D24 TBC1 domain family member 24 0.060 0.602 0.722 5.95E-03 2
Q9BPX5 ARPC5L Actin-related protein 2/3 complex subunit 5-like protein 0.185 0.559 0.555 2.22E-02 2
O14561 NDUFAB1 Acyl carrier protein, mitochondrial 0.298 1.098 1.348 3.93E-03 2
O75369–8 FLNB Isoform 8 of Filamin-B 0.227 0.328 0.285 1.01E-03 3
Q00610 CLTC Clathrin heavy chain 1 0.308 0.441 0.228 4.08E-02 3
J3KN67 TPM3 Tropomyosin alpha-3 chain 0.457 0.520 0.322 4.52E-02 3
P06753–6 TPM3 Isoform 6 of Tropomyosin alpha-3 chain 0.469 0.524 0.313 3.96E-02 3
P06753–5 TPM3 Isoform 5 of Tropomyosin alpha-3 chain 0.472 0.526 0.306 4.24E-02 3
P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0.874 2.055 0.978 2.16E-04 3
P08670 VIM Vimentin 0.261 0.356 0.236 4.92E-03 3
P07196 NEFL Neurofilament light polypeptide 0.203 0.324 0.246 2.50E-02 3
Q96G03 PGM2 Phosphoglucomutase-2 0.121 0.358 0.078 3.00E-02 3
Q06830 PRDX1 Peroxiredoxin-1 0.145 0.420 0.258 4.56E-02 3
B1AVU8 PSAP Saposin-D 0.162 0.191 0.094 5.99E-03 3
P07602–3 PSAP Isoform Sap-mu-9 of Prosaposin 0.164 0.212 0.095 5.11E-03 3
P21709 EPHA1 Ephrin type-A receptor 1 0.182 0.277 0.121 4.30E-02 3
Q16555 DPYSL2 Dihydropyrimidinase-related protein 2 0.104 0.181 0.075 4.27E-02 3
Q14194–2 CRMP1 Isoform LCRMP-1 of Dihydropyrimidinase-related protein 1 0.151 0.277 0.125 3.45E-02 3
P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0.165 0.270 0.147 3.14E-02 3
P08590 MYL3 Myosin light chain 3 1.198 1.510 0.843 1.81E-04 3
P12829 MYL4 Myosin light chain 4 1.062 1.285 0.533 7.30E-03 3
P07585 DCN Decorin 0.556 0.760 0.456 2.03E-04 3
P62937 PPIA Peptidyl-prolyl cis-trans isomerase A 0.103 0.361 0.167 3.55E-03 3
P62937–2 PPIA Isoform 2 of Peptidyl-prolyl cis-trans isomerase A 0.089 0.344 0.145 7.81E-03 3
Q9Y625 GPC6 Glypican-6 0.217 0.365 0.210 7.29E-03 3
P21810 BGN Biglycan 0.715 0.887 0.458 2.16E-04 3
P62158 CALM1 Calmodulin 0.231 0.435 0.161 7.64E-03 3
P09211 GSTP1 Glutathione S-transferase P 0.089 0.363 0.169 1.58E-02 3
P19338 NCL Nucleolin 0.281 0.481 0.380 2.21E-02 3
Q9BRF8 CPPED1 Serine/threonine-protein phosphatase CPPED1 0.215 0.518 0.305 7.44E-03 3
P03950 ANG Angiogenin 0.166 0.318 0.166 3.53E-02 3
Q9UBQ0 VPS29 Vacuolar protein sorting-associated protein 29 0.203 0.503 0.243 2.67E-02 3
P12104 FABP2 Fatty acid-binding protein, intestinal 0.265 0.438 0.092 9.69E-03 3
Q9NQ30 ESM1 Endothelial cell-specific molecule 1 0.705 0.956 0.747 2.08E-04 3
P50897 PPT1 Palmitoyl-protein thioesterase 1 0.153 0.373 0.088 4.45E-03 3
P36543 ATP6V1E1 V-type proton ATPase subunit E 1 0.224 0.269 0.245 2.71E-02 3
P30405 PPIF Peptidyl-prolyl cis-trans isomerase F, mitochondrial 0.644 1.610 0.612 4.01E-03 3
P20674 COX5A Cytochrome c oxidase subunit 5A, mitochondrial 1.036 1.534 0.594 1.11E-02 3
Q09028 RBBP4 Histone-binding protein RBBP4 0.317 0.671 0.315 4.27E-02 3
P02585 TNNC2 Troponin C, skeletal muscle 0.519 0.607 0.274 2.12E-02 3
O43447 PPIH Peptidyl-prolyl cis-trans isomerase H 0.125 0.359 0.195 2.12E-02 3
Q96G01 BICD1 Protein bicaudal D homolog 1 0.332 0.427 0.331 2.65E-02 3
O75380 NDUFS6 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial 0.377 1.066 0.656 2.12E-02 3
P18206 VCL Vinculin 0.102 0.211 0.438 1.88E-03 4
P26038 MSN Moesin 0.065 0.168 0.264 1.26E-02 4
P15311 EZR Ezrin 0.026 0.203 0.443 1.11E-02 4
P35241–5 RDX Isoform 5 of Radixin 0.070 0.253 0.419 7.64E-03 4
P11216 PYGB Glycogen phosphorylase, brain form 0.133 0.469 0.791 4.01E-03 4
P34932 HSPA4 Heat shock 70 kDa protein 4 0.039 0.126 0.297 1.02E-02 4
P11142 HSPA8 Heat shock cognate 71 kDa protein 0.111 0.419 0.729 2.58E-04 4
P08107 HSPA1A Heat shock 70 kDa protein 1A/1B 0.095 0.444 0.760 6.71E-04 4
P17066 HSPA6 Heat shock 70 kDa protein 6 0.138 0.559 0.885 2.45E-04 4
P14618–2 PKM Isoform M1 of Pyruvate kinase PKM 0.075 0.401 0.910 2.03E-04 4
P14618 PKM Pyruvate kinase PKM 0.077 0.381 0.880 2.32E-04 4
P06732 CKM Creatine kinase M-type 0.260 1.108 1.827 5.93E-05 4
P12277 CKB Creatine kinase B-type 0.273 1.113 1.760 5.93E-05 4
P31150 GDI1 Rab GDP dissociation inhibitor alpha 0.065 0.159 0.257 7.26E-03 4
P04075–2 ALDOA Isoform 2 of Fructose-bisphosphate aldolase A −0.015 0.204 0.547 4.89E-04 4
P09972 ALDOC Fructose-bisphosphate aldolase C −0.019 0.128 0.527 5.42E-03 4
P36871 PGM1 Phosphoglucomutase-1 0.086 0.581 1.139 8.28E-04 4
P06744 GPI Glucose-6-phosphate isomerase 0.221 0.859 1.331 4.88E-04 4
P00338 LDHA l-lactate dehydrogenase A chain 0.075 0.192 0.383 2.21E-02 4
P07195 LDHB l-lactate dehydrogenase B chain 0.051 0.243 0.694 7.48E-04 4
P07864 LDHC l-lactate dehydrogenase C chain 0.087 0.299 0.639 1.60E-03 4
P52209 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0.083 0.269 0.385 1.78E-02 4
Q6ZN40 TPM1 Tropomyosin 1 (Alpha), isoform CRA f 0.321 0.642 0.940 2.57E-04 4
H0YK48 TPM1 Tropomyosin alpha-1 chain 0.325 0.614 0.892 1.93E-03 4
P09493–4 TPM1 Isoform 4 of Tropomyosin alpha-1 chain 0.313 0.616 0.894 1.78E-03 4
P55786 NPEPPS Puromycin-sensitive aminopeptidase 0.109 0.281 0.553 2.08E-04 4
P55786–2 NPEPPS Isoform 2 of Puromycin-sensitive aminopeptidase 0.107 0.278 0.557 2.16E-04 4
A2A274 ACO2 Aconitate hydratase, mitochondrial 0.021 0.497 1.364 2.79E-03 4
P13929 ENO3 Beta-enolase 0.173 0.641 0.974 2.43E-03 4
P09104 ENO2 Gamma-enolase 0.111 0.300 0.502 6.15E-04 4
P17174 GOT1 Aspartate aminotransferase, cytoplasmic −0.012 0.559 1.330 5.12E-04 4
P02545 LMNA Prelamin-A/C 0.096 0.254 0.410 3.43E-02 4
P62258 YWHAE 14–3-3 protein epsilon 0.183 0.504 0.751 5.12E-04 4
P61981 YWHAG 14–3-3 protein gamma 0.161 0.455 0.722 2.16E-04 4
P40925–3 MDH1 Isoform 3 of Malate dehydrogenase, cytoplasmic 0.101 1.045 1.823 1.14E-04 4
P78417 GSTO1 Glutathione S-transferase omega-1 0.071 0.276 0.510 1.09E-02 4
P20810–6 CAST Isoform 6 of Calpastatin 0.123 0.401 0.550 3.24E-03 4
P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial 0.108 0.552 0.919 7.57E-03 4
P42765 ACAA2 3-ketoacyl-CoA thiolase, mitochondrial 0.062 0.517 0.938 2.88E-02 4
P18669 PGAM1 Phosphoglycerate mutase 1 0.162 0.710 1.002 1.27E-03 4
P17540 CKMT2 Creatine kinase S-type, mitochondrial 0.366 1.105 1.568 1.11E-04 4
Q16881–5 TXNRD1 Isoform 5 of Thioredoxin reductase 1, cytoplasmic 0.039 0.163 0.280 1.33E-02 4
Q16881–3 TXNRD1 Isoform 3 of Thioredoxin reductase 1, cytoplasmic 0.039 0.164 0.278 1.20E-02 4
P99999 CYCS Cytochrome c 0.058 0.964 1.780 2.16E-04 4
Q15124 PGM5 Phosphoglucomutase-like protein 5 0.251 0.908 1.369 1.11E-04 4
P31153 MAT2A S-adenosylmethionine synthase isoform type-2 0.055 0.188 0.460 3.64E-02 4
P11766 ADH5 Alcohol dehydrogenase class-3 0.080 0.666 1.127 2.08E-04 4
P25786–2 PSMA1 Isoform Long of Proteasome subunit alpha type-1 0.056 0.260 0.450 3.91E-02 4
P16083 NQO2 Ribosyldihydronicotinamide dehydrogenase [quinone] 0.051 0.229 0.459 3.35E-02 4
O14818 PSMA7 Proteasome subunit alpha type-7 0.105 0.197 0.400 3.19E-02 4
P21266 GSTM3 Glutathione S-transferase Mu 3 0.120 0.355 0.617 3.32E-04 4
P28161 GSTM2 Glutathione S-transferase Mu 2 0.084 0.419 0.734 4.47E-03 4
E9PHN7 GSTM2 Glutathione S-transferase Mu 2 0.094 0.404 0.736 5.74E-03 4
P09488 GSTM1 Glutathione S-transferase Mu 1 0.126 0.335 0.679 1.01E-02 4
Q03013 GSTM4 Glutathione S-transferase Mu 4 0.112 0.328 0.668 1.06E-02 4
Q96CN7 ISOC1 Isochorismatase domain-containing protein 1 0.026 0.250 0.717 8.16E-03 4
Q9NQW7–3 XPNPEP1 Isoform 3 of Xaa-Pro aminopeptidase 1 0.042 0.166 0.390 3.62E-03 4
P49721 PSMB2 Proteasome subunit beta type-2 0.070 0.263 0.403 2.43E-02 4
P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0.068 0.048 0.323 3.37E-02 4
P25789 PSMA4 Proteasome subunit alpha type-4 0.084 0.265 0.508 3.49E-02 4
H0YLC2 PSMA4 Proteasome subunit alpha type 0.080 0.270 0.505 4.04E-02 4
P62140 PPP1CB Serine/threonine-protein phosphatase PP1-beta catalytic subunit 0.096 0.227 0.335 3.31E-03 4
P62136 PPP1CA Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 0.089 0.188 0.311 1.12E-02 4
P36873–2 PPP1CC Isoform Gamma-2 of Serine/threonine-protein phosphatase PP1-gamma catalytic subunit 0.085 0.204 0.310 8.50E-03 4
P55809 OXCT1 Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial 0.023 0.106 0.812 2.61E-03 4
P09417 QDPR Dihydropteridine reductase 0.040 0.311 0.631 1.57E-02 4
Q9ULA0 DNPEP Aspartyl aminopeptidase 0.072 0.308 0.562 3.17E-04 4
E7ETB3 DNPEP Aspartyl aminopeptidase 0.066 0.311 0.577 3.89E-04 4
P28074 PSMB5 Proteasome subunit beta type-5 −0.031 0.157 0.372 4.54E-02 4
Q9NZL9 MAT2B Methionine adenosyltransferase 2 subunit beta 0.067 0.114 0.386 2.88E-02 4
P41250 GARS Glycine–tRNA ligase 0.053 0.179 0.302 2.49E-02 4
P55083–2 MFAP4 Isoform 2 of Microfibril-associated glycoprotein 4 0.111 0.215 0.350 1.56E-02 4
Q5JSH3 WDR44 WD repeat-containing protein 44 0.062 0.151 0.284 3.70E-02 4
Q8NCW5 APOA1BP NAD(P)H-hydrate epimerase 0.044 0.290 0.642 1.56E-03 4
Q9Y3B8–3 REXO2 Isoform 3 of Oligoribonuclease, mitochondrial 0.046 0.700 0.940 2.42E-03 4
P30046 DDT d-dopachrome decarboxylase 0.074 0.426 0.695 4.26E-02 4
Q8IW45 CARKD ATP-dependent (S)-NAD(P)H-hydrate dehydratase 0.030 0.340 0.645 3.78E-02 4
P53041 PPP5C Serine/threonine-protein phosphatase 5 0.116 0.323 0.673 1.97E-03 4
P26022 PTX3 Pentraxin-related protein PTX3 0.122 0.501 0.762 4.79E-04 4
P34949 MPI Mannose-6-phosphate isomerase 0.188 0.345 0.662 5.52E-04 4
Q06124 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 −0.047 0.143 0.297 3.00E-02 4
Q96HC4–6 PDLIM5 Isoform 6 of PDZ and LIM domain protein 5 0.090 0.340 0.518 2.65E-02 4
Q96HC4 PDLIM5 PDZ and LIM domain protein 5 0.116 0.245 0.419 4.08E-02 4
O75390 CS Citrate synthase, mitochondrial 0.004 0.325 1.456 5.12E-04 4
P61457 PCBD1 Pterin-4-alpha-carbinolamine dehydratase 0.156 0.408 1.044 1.71E-02 4
P28070 PSMB4 Proteasome subunit beta type-4 0.138 0.213 0.364 6.68E-03 4
J3QL71 SCRN2 Secernin-2 0.036 0.146 0.327 1.66E-02 4
O95817 BAG3 BAG family molecular chaperone regulator 3 0.118 0.346 0.513 1.45E-02 4
P45379 TNNT2 Troponin T, cardiac muscle −0.067 0.432 1.743 5.07E-03 4
K7ER74 APOC4-APOC2 Protein APOC4-APOC2 −0.879 −0.574 0.495 1.56E-03 4
P55056 APOC4 Apolipoprotein C-IV −0.517 −0.231 0.336 4.73E-02 4
P61601 NCALD Neurocalcin-delta 0.028 0.181 0.241 3.17E-02 4
P63316 TNNC1 Troponin C, slow skeletal and cardiac muscles 0.320 0.370 1.313 2.19E-03 4
Q6ICJ4 Em:AP000351.3 Em:AP000351.3 protein −0.062 0.398 0.893 4.61E-02 4
O75367 H2AFY Core histone macro-H2A.1 0.220 0.354 0.711 3.44E-02 4
O75112 LDB3 LIM domain-binding protein 3 0.035 0.269 0.616 1.94E-02 4
Q96GD0 PDXP Pyridoxal phosphate phosphatase 0.144 0.171 0.363 2.81E-02 4
Q99598 TSNAX Translin-associated protein X 0.129 0.200 0.362 4.27E-02 4
P46976 GYG1 Glycogenin-1 −0.036 0.440 0.724 2.42E-02 4
Q8WZA9 IRGQ Immunity-related GTPase family Q protein 0.101 0.187 0.540 3.00E-02 4
P49748–3 ACADVL Isoform 3 of Very long-chain specific acyl-CoA dehydrogenase, mitochondrial −0.156 0.874 2.159 1.69E-02 4
Q14896 MYBPC3 Myosin-binding protein C, cardiac-type −0.092 0.140 0.719 4.59E-02 4
P38646 HSPA9 Stress-70 protein, mitochondrial 0.109 0.507 0.821 6.15E-04 4
P19429 TNNI3 Troponin I, cardiac muscle −0.189 0.265 1.725 2.19E-02 4
P22888 LHCGR Lutropin-choriogonadotropic hormone receptor 0.077 0.642 1.124 1.21E-02 4
Q5TZA2 CROCC Rootletin −0.022 0.159 0.623 1.67E-02 4
Q5TZA2–2 CROCC Isoform 2 of Rootletin −0.048 0.170 0.634 1.12E-02 4
Q13356–2 PPIL2 Isoform 2 of Peptidyl-prolyl cis-trans isomerase-like 2 0.037 0.114 0.556 3.72E-02 4
Q9H7B2 RPF2 Ribosome production factor 2 homolog 0.500 0.247 1.091 3.19E-02 4
Q07954 LRP1 Prolow-density lipoprotein receptor-related protein 1 −0.120 −0.155 −0.161 3.00E-02 5
P04114 APOB Apolipoprotein B-100 −0.537 −0.583 −0.071 2.35E-02 5
P01009 SERPINA1 Alpha-1-antitrypsin −0.583 −0.591 −0.193 4.61E-02 5
P49747 COMP Cartilage oligomeric matrix protein −0.084 −0.101 −0.181 4.57E-02 5
P03952 KLKB1 Plasma kallikrein −0.555 −0.618 −0.660 3.29E-02 5
P01871 IGHM Ig mu chain C region −0.185 −0.195 −0.062 2.34E-02 5
P04220 Ig mu heavy chain disease protein −0.181 −0.177 −0.059 1.72E-02 5
Q12805 EFEMP1 EGF-containing fibulin-like extracellular matrix protein 1 −0.410 −0.393 −0.457 1.39E-02 5
Q12805–5 EFEMP1 Isoform 5 of EGF-containing fibulin-like extracellular matrix protein 1 −0.416 −0.415 −0.460 1.63E-02 5
O75197 LRP5 Low-density lipoprotein receptor-related protein 5 −0.157 −0.231 −0.204 3.91E-02 5
P04083 ANXA1 Annexin A1 −0.349 −0.348 −0.335 1.11E-03 5
Q86U17 SERPINA11 Serpin A11 −0.215 −0.160 −0.350 2.28E-02 5
P18428 LBP Lipopolysaccharide-binding protein −0.348 −0.504 −0.476 3.13E-02 5
Q96CX2 KCTD12 BTB/POZ domain-containing protein KCTD12 −0.076 −0.116 −0.274 3.18E-02 5
Q9BXD5 NPL N-acetylneuraminate lyase −0.144 −0.286 −0.279 1.37E-02 5
Q6V0I7 FAT4 Protocadherin Fat 4 −0.106 −0.231 −0.236 4.32E-02 5
P14222 PRF1 Perforin-1 −0.130 −0.182 −0.248 1.88E-03 5
O15240 VGF Neurosecretory protein VGF −0.119 −0.325 −0.174 4.45E-02 5
Q96MU8–2 KREMEN1 Isoform 2 of Kremen protein 1 −0.209 −0.246 −0.193 7.30E-03 5
P09525 ANXA4 Annexin A4 −0.330 −0.442 −0.094 1.02E-02 5
P08236 GUSB Beta-glucuronidase −0.421 −0.437 −0.199 1.86E-02 5
B0YIW2 APOC3 Apolipoprotein C-III −1.089 −1.115 −0.405 1.74E-02 5
Q5SPY9 NPDC1 Neural proliferation differentiation and control protein 1 −0.111 −0.263 −0.298 5.67E-03 5
P04211 Ig lambda chain V region 4A −1.026 −0.813 −0.730 1.71E-02 5
Q92794 KAT6A Histone acetyltransferase KAT6A −0.490 −0.595 −0.047 3.68E-02 5
Q8N201 INTS1 Integrator complex subunit 1 −0.254 −0.328 −0.314 1.02E-02 5
Q2WGJ9 FER1L6 Fer-1-like protein 6 −0.474 −0.314 −0.124 2.65E-02 5
P54707–2 ATP12A Isoform 2 of Potassium-transporting ATPase alpha chain 2 −0.253 −0.424 −0.252 8.50E-03 5
Q5VT52 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 −0.430 −0.601 −0.434 1.76E-03 5
Q9UNN5 FAF1 FAS-associated factor 1 −0.882 −0.640 −0.230 1.21E-02 5
Q8TE49–2 OTUD7A Isoform 2 of OTU domain-containing protein 7A −1.744 −1.530 −1.217 3.78E-03 5
O15072 ADAMTS3 A disintegrin and metalloproteinase with thrombospondin motifs 3 −0.110 −0.098 −0.487 2.04E-02 5
Q6B0I6 KDM4D Lysine-specific demethylase 4D −1.120 −0.693 −0.551 4.60E-02 5
Q9NUL3 STAU2 Double-stranded RNA-binding protein Staufen homolog 2 −0.232 −0.548 −0.574 2.08E-02 5
J3KPX5 DNA2 DNA replication ATP-dependent helicase/nuclease DNA2 −0.266 −0.167 −0.109 4.91E-02 5
Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 −0.318 −0.410 −0.065 3.64E-02 5
Q15761 NPY5R Neuropeptide Y receptor type 5 −0.191 −0.544 −0.531 4.66E-02 5
Q9Y6Y0 IVNS1ABP Influenza virus NS1A-binding protein −0.116 −0.356 −0.104 4.48E-02 5
P09493–6 TPM1 Isoform 6 of Tropomyosin alpha-1 chain 0.335 0.635 0.906 6.15E-04 NA
E7EVY3 CAST Calpastatin 0.129 0.405 0.536 4.11E-03 NA
Q99983 OMD Osteomodulin 0.067 0.139 0.196 1.15E-02 NA
Q9Y5Z4 HEBP2 Heme-binding protein 2 0.110 0.481 0.277 4.26E-02 NA
P49354 FNTA Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha 0.044 0.255 0.330 2.71E-02 NA
P31040 SDHA Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 0.093 1.056 1.311 9.41E-03 NA
P61224 RAP1B Ras-related protein Rap-1b 0.294 0.361 0.363 2.96E-02 NA
P14174 MIF Macrophage migration inhibitory factor 0.265 0.779 0.499 3.94E-03 NA
Q15843 NEDD8 NEDD8 0.039 0.200 0.258 2.79E-03 NA
O94913 PCF11 Pre-mRNA cleavage complex 2 protein Pcf11 0.209 0.141 0.210 2.61E-03 NA

a Benjamini-Hochberg corrected p values are reported.

b 323 out of 333 regulated proteins were clustered into 5 distinct clusters using Fuzzy C-means clustering. Proteins were assigned into clusters using membership value of > 0.7. Proteins with a membership value in between 0.5 and 0.7 weren't assigned to any cluster and marked as NA.

HHS Vulnerability Disclosure