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. 2015 Jul 20;125(8):3269–3279. doi: 10.1172/JCI76765

Figure 3. Conditional inactivation of IRE1α results in increased bone volume and decreased osteoclast number in vivo.

Figure 3

(A) Reconstituted 3D images of the distal femur. Scale bars: 0.5 mm. (B) μCT-based structural analysis of the femur (n = 6 mice/group). BV/TV, bone volume/tissue volume; Tb.Th, trabecular thickness; Tb.N, trabecular number; Tb.Sp, trabecular space. Values represent mean ± SD. **P < 0.005. (C) Histomorphometric analysis of the tibial metaphysis (n = 7 mice/group). ES/BS, erosion surface/bone surface; Oc.S/BS, osteoclast surface/bone surface; N.Oc/BS, osteoclast number/bone surface. Values represent mean ± SD. *P < 0.05. (D) Sections of the tibial metaphysis stained for TRAP. Scale bar: 200 μm. Statistical analysis was performed using Student’s t test.