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. 2015 Jul 13;125(8):3226–3240. doi: 10.1172/JCI80883

Figure 6. Exogenous TGF-β1 rapidly suppresses CCI-induced enhancement of excitatory synaptic transmission in lamina IIo neurons of spinal cord slices via the TGF-β1R.

Figure 6

(A) Traces showing sEPSCs in lamina IIo neurons of spinal cord slices. (B) Frequency and amplitude of sEPSCs. CCI (day 4) induced profound increases in sEPSC frequency and amplitude, which were suppressed by TGF-β1 (2 or 10 ng/ml). Note that TGF-β1 had no effect on the frequency or amplitude of sEPSCs in sham control spinal cord. *P < 0.05, compared with sham surgery; #P < 0.05 compared with the control group; n = 5 neurons/group. (C) The TGF-β1R antagonist SB431542 blocked TGF-β1–induced inhibition of sEPSC frequency and amplitude. *P < 0.05; n = 5 neurons/group. Statistical significance was determined by 1-way ANOVA, followed by Bonferroni’s post-hoc test. All data are expressed as the mean ± SEM.