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. 2015 Jul 13;125(8):3087–3102. doi: 10.1172/JCI81317

Figure 7. Ankb knockin mice are more susceptible to HFD-induced metabolic derangements and obesity.

Figure 7

(A) Representative images of 3-month-old Ankb+/+, AnkbL1622I/L1622I, and AnkbR1788W/R1788W mice fed either a control or a HFD for 12 weeks. (B) Body weight. (C) Epididymal fat-pad weights. (D) Blood glucose levels in response to oral glucose (2 mg/kg body weight) during an OGTT. (E) Area under the curve for OGTT. (F) Blood glucose levels in response to insulin administration (0.75 U/kg body weight). (G) Area under the curve for the intraperitoneal insulin tolerance test (ITT). Data represent mean ± SEM (n = 12 mice per group for 1 experiment). *P < 0.05, **P < 0.01, ***P < 0.001, 1-way ANOVA with post-hoc Tukey test.