Figure 7.

Enforced re-expression of the CB₁ receptor rescues HD-like striatal atrophy in R6/2 mice. R6/2 mice (3.5–4 weeks old) and WT littermates were injected stereotactically into the dorsolateral striatum with a recombinant adeno-associated virus (AAV) encoding HA-tagged CB₁ receptor or empty vector as control (n=10–12 animals per group). The volume of the striatum and lateral ventricles relative to total brain volume of 8-week-old animals is represented. Representative MRI pictures are shown. Striata are outlined. Data were analyzed using unpaired Student's t-test. **P<0.01 from the corresponding WT-empty group; ^##P<0.01 from the corresponding R6/2-empty group