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Pharmacodynamic responses for Rh30 xenografts. Tumor-bearing mice were administered RG7388 (80 mg/kg) daily for 3 days with or without XRT (2 Gy daily × 3). Tumors were harvested at the indicated times during treatment and 24 and 48 Hr after the final dose of XRT. DDB2, p21 and GAPDH were determined using a Protein Simple machine, other samples were determined using conventional immunoblotting as described in Materials and Methods.
