Table 1.

Summary of major phenotypes identified in Nfi null mice.

Phenotype	Nfia KO	Nfib KO	Nfic KO	Nfvc KO
Survival	Majority die at birth (das Neves et al., 1999).	All die at birth (Grunder et al., 2002).	Survive to adulthood (Steele-Perkins et al., 2003).	Postnatal lethal (3–4 week)
CNS	Delayed glial and neuronal differentiation (Piper et al., 2010). Corpus callosum agenesis.	Delayed glial and neuronal differentiation (Barry et al., 2008; Betancourt et al., 2014; Piper et al., 2014).	Phenotype not examined. Weak expression detected in developing CNS (Chaudhry et al., 1997).	Delayed glial and neuronal differentiation (Heng et al., 2014).
	Communicating hydrocephalus (das Neves et al., 1999).		Corpus callosum dysgenesis (Steele-Perkins et al., 2005).	Corpus callosum dysgenesis (Plachez et al., 2008).
Lung	No obvious phenotype. Expressed in developing lung (Steele-Perkins et al., 2005).	Severe lung hyperplasia. Die from respiratory defects (Steele-Perkins et al., 2005).	Phenotype not examined. Expressed in developing lung (Steele-Perkins et al., 2005).	Phenotype not examined. Expressed in developing lung (Steele-Perkins et al., 2005).
Muscle and skeletal tissue	No gross skeletal defects (das Neves et al., 1999).	Skeletal and muscular phenotype not examined. Expressed by muscle progenitors (Biressi et al., 2007b).	Skeletal and muscular phenotype not examined. Expressed by muscle progenitors (Biressi et al., 2007b).	Reduced and disorganized musculature (Messina et al., 2010).
	Musculature not examined, expressed by muscle progenitors (Biressi et al., 2007b).			Kyphosis and reduced bone density (Driller et al., 2007).
Other	Abnormal ureteropelvic and ureterovesical junctions, bifid and megaureter (Lu et al., 2007).	-	Multiple tooth pathologies (Steele-Perkins et al., 2003).	-
			Wound healing defects (Plasari et al., 2009).