Survival |
Majority die at birth (das Neves et al., 1999). |
All die at birth (Grunder et al., 2002). |
Survive to adulthood (Steele-Perkins et al., 2003). |
Postnatal lethal (3–4 week) |
CNS |
Delayed glial and neuronal differentiation (Piper et al., 2010). Corpus callosum agenesis. |
Delayed glial and neuronal differentiation (Barry et al., 2008; Betancourt et al., 2014; Piper et al., 2014). |
Phenotype not examined. Weak expression detected in developing CNS (Chaudhry et al., 1997). |
Delayed glial and neuronal differentiation (Heng et al., 2014). |
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Communicating hydrocephalus (das Neves et al., 1999). |
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Corpus callosum dysgenesis (Steele-Perkins et al., 2005). |
Corpus callosum dysgenesis (Plachez et al., 2008). |
Lung |
No obvious phenotype. Expressed in developing lung (Steele-Perkins et al., 2005). |
Severe lung hyperplasia. Die from respiratory defects (Steele-Perkins et al., 2005). |
Phenotype not examined. Expressed in developing lung (Steele-Perkins et al., 2005). |
Phenotype not examined. Expressed in developing lung (Steele-Perkins et al., 2005). |
Muscle and skeletal tissue |
No gross skeletal defects (das Neves et al., 1999). |
Skeletal and muscular phenotype not examined. Expressed by muscle progenitors (Biressi et al., 2007b). |
Skeletal and muscular phenotype not examined. Expressed by muscle progenitors (Biressi et al., 2007b). |
Reduced and disorganized musculature (Messina et al., 2010). |
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Musculature not examined, expressed by muscle progenitors (Biressi et al., 2007b). |
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Kyphosis and reduced bone density (Driller et al., 2007). |
Other |
Abnormal ureteropelvic and ureterovesical junctions, bifid and megaureter (Lu et al., 2007). |
- |
Multiple tooth pathologies (Steele-Perkins et al., 2003). |
- |
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Wound healing defects (Plasari et al., 2009). |
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